Evidence map›Paper›PMID 40359334›Full record

ReviewEuropean journal of immunology2025

Regulation and Function of the Atypical IκBs-Bcl-3, IκB

Tanja Kübelbeck, Nina Olivera Wichmann, Timsse Raj, Cynthia Raj, Caspar Ohnmacht, Nadine Hövelmeyer, Daniela Kramer, Vigo Heissmeyer

Abstract readReview
In one paragraph

Review in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tanja KübelbeckDepartment of Dermatology, University Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany.
Nina Olivera WichmannCenter of Allergy and Environment (ZAUM), Technical University and Helmholtz Zentrum München, Munich, Germany.
Timsse RajInstitute for Immunology, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried, Germany.
Cynthia RajInstitute for Molecular Medicine Mainz, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Caspar OhnmachtCenter of Allergy and Environment (ZAUM), Technical University and Helmholtz Zentrum München, Munich, Germany.
Nadine HövelmeyerInstitute for Molecular Medicine Mainz, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Daniela KramerDepartment of Dermatology, University Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany.
Vigo HeissmeyerInstitute for Immunology, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität in Munich, Planegg-Martinsried, Germany.

Funding

Deutsche Forschungsgemeinschaft TRR355/1 project number 490846870
6 · The paper itself

Abstract

Signaling pathways involving NF-κB transcription factors have essential roles in inflammation, immunity, cell proliferation, differentiation, and survival. Classical IκB proteins, such as IκBα and IκBβ, bind to NF-κB via ankyrin repeats to sequester NF-κB in the cytoplasm and thus suppress NF-κB activity. Unlike these constitutively expressed classical IκBs, the expression of the atypical IκBs Bcl-3, IκB

Indexed as

AutoimmunityI-kappa B ProteinsLymphocytesAnimalsB-Cell Lymphoma 3 ProteinGene Expression RegulationHumansNF-kappa BSignal TransductionB-Cell Lymphoma 3 ProteinBCL3 protein, humanI-kappa B ProteinsNF-kappa BautoimmunityBcl3lymphocytesNfkbidNfkbizNF‐κB

Identifiers

PMID40359334
PMCPMC12074568

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.