Evidence map›Paper›PMID 40359302›Full record

ArticleEnvironmental health perspectives2025

Effects of Bisphenol A and Retinoic Acid Exposure on Neuron and Brain Formation: A Study in Human Induced Pluripotent Stem Cells and Zebrafish Embryos.

Tomomi Nishie, Tomoki Taya, Shunichi Omori, Kenya Ueno, Yoshinori Okamoto, Shogo Higaki, Marina Oka, Yachiyo Mitsuishi, Taiga Tanaka, Mana Nakamoto and 16 more

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In one paragraph

Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Tomomi NishieDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Tomoki TayaDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Shunichi OmoriDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Kenya UenoDepartment of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Yoshinori OkamotoFaculty of Pharmacy, Meijo University, Nagoya, Japan.
Shogo HigakiDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Marina OkaDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Yachiyo MitsuishiDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Taiga TanakaDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Mana NakamotoDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Hideaki KawaharaDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Natsuki TeraguchiDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Tomoyuki KotakaDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Misaki SawabeDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Miu TakahashiDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Shoko KitaikeDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Minori WadaDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Keiko IidaDepartment of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Akihiro YamashitaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Osaka University, Osaka, Japan.
Hideto JinnoFaculty of Pharmacy, Meijo University, Nagoya, Japan.
Atsuhiko IchimuraDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Ikuo TooyamaMolecular Neuroscience Research Center and Medical Innovation Research Center, Shiga University of Medical Science, Shiga, Japan.
Noriyoshi SakaiDepartment of Gene Function and Phenomics, National Institute of Genetics, Mishima, Japan.
Masahiko HibiGraduate School of Science, Nagoya University, Nagoya, Japan.
Akira HirasawaDepartment of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Tatsuyuki TakadaDepartment of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.ORCID 0000-0002-6967-7402

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeveloping human fetuses may be exposed to the chemical compound bisphenol A (BPA), and retinoic acid (RA) has been detected at low levels in water sources. RA signaling regulates key developmental genes and is essential for organ development, including the brain. We previously reported that RA/BPA coexposure of mouse embryonic stem cells potentiates RA signaling, which warrants further investigation.

objectiveThis study was undertaken in human induced pluripotent stem cells (iPSCs) and zebrafish embryos to investigate whether coexposure to BPA and exogenous RA could potentiate

methodsHuman iPSCs and zebrafish embryos were exposed to exogenous RA (0, 7.5, 10, 12.5, 100, 200 or

resultsIn both iPSCs and zebrafish, RA/BPA coexposure had higher expression of 3'

conclusionOur findings suggest a mechanistic link between chemical exposure and neurodevelopmental impairments and demonstrate involvement of exogenous RA signaling in endocrine disruption. Further investigation is needed to explore why BPA alone did not affect endogenous RA signaling, whereas exogenous RA signaling was potentiated with RA/BPA coexposure. https://doi.org/10.1289/EHP15574.

Indexed as

Benzhydryl CompoundsBrainInduced Pluripotent Stem CellsNeuronsPhenolsTretinoinWater Pollutants, ChemicalAnimalsBisphenol A CompoundsEmbryo, NonmammalianHumansZebrafishBenzhydryl Compoundsbisphenol ABisphenol A CompoundsPhenolsTretinoinWater Pollutants, Chemical

Identifiers

PMID40359302
PMCPMC12165739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.