Evidence map›Paper›PMID 40359291›Full record

ArticleEuropean journal of gastroenterology & hepatology2025

Primary intrahepatic lithiasis in western countries: role of ultrasound and comparison with MRI with MRCP.

Marie-Pierre Vullierme, Christophe Desterke, Sophie Hillaire, Béatrice Parfait, Valérie Vilgrain, Vinciane Rebours, Maïté Lewin

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of gastroenterology & hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Marie-Pierre VulliermeDepartment of Radiology, Paul Brousse University Hospital, Paris-Cité University, Villejuif, France.
Christophe DesterkeINSERM U1310, Paris-Saclay University, Medicine Faculty, Paul Brousse University Hospital, Villejuif, France.
Sophie HillaireDepartment of Hepatology, Beaujon University Hospital, Clichy, AP-HP, Paris-Cité University, Clichy, France.
Béatrice ParfaitDepartment of Genomic Medicine, Cochin University Hospital, Paris, AP-HP Paris-Cité University, Paris, France.
Valérie VilgrainDepartment of Radiology, Beaujon University Hospital, Clichy, AP-HP, Paris-Cité University, Clichy, France.
Vinciane ReboursDepartment of Pancreatology and digestive oncology, Beaujon University Hospital, Clichy, AP-HP, Paris-Cité University, Clichy, France.
Maïté LewinDepartment of Radiology, Paul Brousse University Hospital, Villejuif, AP-HP, Paris-Saclay University, Villejuif, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study hepatobiliary expert ultrasound (US) in a cohort of suspected primary intrahepatic lithiasis (IHL) and to compare these findings with MRI/MRCP data.

methodsAll patients with a diagnosis of primary-IHL based upon biological and, or, clinical symptoms who underwent US between 2008 and 2023 were retrospectively enrolled in two tertiary hepatobiliary centers. Clinical characteristics, available genetic and radiological features (expert US and MRCP) were recorded. Data were compared for the presence of comet-tail images or stones on US, between US and MRCP features and between imaging and patients' genetic status. Statistical analyses were performed with R software environment version 4.2.1, by univariate and multivariate analysis.

resultsA total of 112 primary-IHL patients were included (mean age 43 years old ±14 and 55% women). US identified primary-IHL in 92/112 (82%) patients including intrahepatic biliary comet-tail in 82/112 (73%) and stones in 51/112 (46%). Among these, 66/112 (68%) had both US and MRCP. Lithiasis was identified in 60/76 US (79%) and 44/76 MRCP (58%). MRCP showed only stones in 22/76, 29%. Genetic testing was performed in 66/112 (58%) patients. Thirty-two (49%) of these patients had pathogenic ABCB4/MDR3 gene variants, 14/66 (21%) other pathogenic variants and 5/66 (5%) had unknown significant variants. No genetic abnormalities were found in 19/66 (29%). A multivariate logistic model with the comet-tail sign as an outcome showed that there was a significant negative correlation between other pathogenic genetic variants and the comet-tail phenotype ( P -value = 0.049).

conclusionUS, and not MRCP, should be the primary diagnostic tool in suspected primary-IHL patients.

Indexed as

Cholangiopancreatography, Magnetic ResonanceMagnetic Resonance ImagingAdultATP Binding Cassette Transporter, Subfamily BFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesUltrasonographyYoung AdultATP Binding Cassette Transporter, Subfamily Bmultidrug resistance protein 3bile ductscholelithiasishepatolithiasisintrahepatic lithiasisMRCPMRIultrasound

Identifiers

PMID40359291
PMCPMC12668295

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