Evidence map›Paper›PMID 40359283›Full record

ArticleThe Journal of infectious diseases2025

A Case Cluster of Aseptic Meningitis Associated With a Newly Identified Recombinant Echovirus 6/Coxsackievirus B1 Enterovirus.

Kartikeya Cherabuddi, Massimiliano S Tagliamonte, John A Lednicky, David A Ostrov, Tracey L Moquin, Vishal Kaushik Thoomkuntla, Brian Bourgeois, Vidya Sagar Kollu, Nicole M Iovine, Paul D Myers and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kartikeya CherabuddiEmerging Pathogens Institute, University of Florida.ORCID 0000-0001-7390-9053
Massimiliano S TagliamonteEmerging Pathogens Institute, University of Florida.ORCID 0000-0003-2699-7331
John A LednickyEmerging Pathogens Institute, University of Florida.ORCID 0000-0003-4069-0539
David A OstrovEmerging Pathogens Institute, University of Florida.ORCID 0000-0002-4696-875X
Tracey L MoquinEmerging Pathogens Institute, University of Florida.
Vishal Kaushik ThoomkuntlaDepartment of Medicine, College of Medicine, University of Florida.
Brian BourgeoisOffice of Infection Control, UFHealth.
Vidya Sagar KolluNorth Florida Regional Medical Center.
Nicole M IovineEmerging Pathogens Institute, University of Florida.ORCID 0000-0002-5032-6485
Paul D MyersAlachua County Health Department, Florida Department of Health.
Kuttichantran SubramaniamEmerging Pathogens Institute, University of Florida.
Marco SalemiEmerging Pathogens Institute, University of Florida.ORCID 0000-0003-0136-2102
J Glenn MorrisEmerging Pathogens Institute, University of Florida.ORCID 0000-0001-9347-1984

Funding

University of Florida Emerging Pathogens Institute
6 · The paper itself

Abstract

A day care teacher presented with complaints of headache, neck stiffness, and fever. Because of initial concerns about meningococcal meningitis, families of day care attendees were notified, and 10 children from the day care presented for evaluation. Cerebrospinal fluid from the teacher and nasal swabs from 4 children who were febrile were positive for enterovirus on reverse transcription polymerase chain reaction. A novel recombinant enterovirus was cultured from the teacher's cerebrospinal fluid and from 2 of the nasal swabs. The amino-terminal portion of the recombinant virus was derived from echovirus 6, with the carboxy-terminal portion originating from coxsackievirus B1; recombinant segments were most closely related to similar segments from strains isolated in France. Recombination occurred within the C2 gene associated with virus replication and virion morphogenesis. Structural modeling predicted that the recombinant protein was capable of forming hexameric and heptameric assemblies. Our data highlight the potential for recombination among enteroviruses, leading to modifications within viral proteins that may affect virulence.

Indexed as

Echovirus 6, HumanEchovirus InfectionsEnterovirus B, HumanMeningitis, AsepticRecombination, GeneticChildChild, PreschoolFemaleHumansMalePhylogenyaseptic meningitiscoxsackievirus B1daycare infectionechovirus 6enterovirus recombinant

Identifiers

PMID40359283
PMCPMC12455311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.