Evidence map›Paper›PMID 40359260›Full record

ArticleScience signaling2025

ADAR2-mediated Q/R editing of GluA2 in homeostatic synaptic plasticity.

Lucy Peterson, Richard Coca, Shreya Parikh, Katrina McCarthy, Heng-Ye Man

Abstract read
In one paragraph

Article in Science signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Age-Related Transcriptomic Changes in the Vermiform Appendix.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucy PetersonDepartment of Biology, Boston University, Boston, MA 02215, USA.ORCID 0000-0002-2649-2424
Richard CocaDepartment of Biology, Boston University, Boston, MA 02215, USA.ORCID 0009-0006-6135-4875
Shreya ParikhDepartment of Biology, Boston University, Boston, MA 02215, USA.
Katrina McCarthyDepartment of Biology, Boston University, Boston, MA 02215, USA.
Heng-Ye ManDepartment of Biology, Boston University, Boston, MA 02215, USA.ORCID 0000-0002-3530-3066

Funding

Molecular mechanisms of homeostatic synaptic plasticityR01MH130600 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Hengye Man · 2023 to 2026
$1.9M
Study of NEXMIF mosaic expression on neuronal development and connectivity in female miceR21MH133014 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MAN, HENGYE · 2023 to 2024
$454k
NIH HHS T32 5T32GM008541-24NIMH NIH HHS R01 MH130600NIMH NIH HHS R21 MH133014
6 · The paper itself

Abstract

Homeostatic synaptic plasticity is a negative feedback mechanism through which neurons modify their synaptic strength to counteract chronic increases or decreases in activity. In response to activity deprivation, synaptic strength is enhanced by increasing the number of AMPA receptors (AMPARs), particularly Ca

Indexed as

Adenosine DeaminaseHomeostasisNeuronal PlasticityReceptors, AMPARNA-Binding ProteinsRNA EditingAnimalsCalciumCells, CulturedMaleMiceMice, Inbred C57BLNeuronsADAR2 protein, mouseAdenosine DeaminaseCalciumglutamate receptor ionotropic, AMPA 2Receptors, AMPARNA-Binding Proteins

Identifiers

PMID40359260
PMCPMC12175841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.