Evidence map›Paper›PMID 40359224›Full record

ArticlePloS one2025

Short-term real-world outcomes of diabetic macular edema treated with intravitreal faricimab.

Toshiaki Hirakata, Fumihiro Hara, Yuta Nochi, Daisuke Shinohara, Shutaro Yamamoto, Yoshimune Hiratsuka, Shintaro Nakao

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Toshiaki HirakataDepartment of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7512-6802
Fumihiro HaraDepartment of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Yuta NochiDepartment of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Daisuke ShinoharaDepartment of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Shutaro YamamotoDepartment of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Yoshimune HiratsukaDepartment of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Shintaro NakaoDepartment of Ophthalmology, Juntendo University Faculty of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Faricimab, a new drug for diabetic macular edema (DME), was made available in Japan in 2022. However, few reports have been published about its treatment outcomes in clinical practice. To assess the short-term outcomes of intravitreal faricimab (IVF) in patients with DME, the records of patients with DME receiving IVF therapy between July 2022 and July 2023 at Juntendo University Hospital were retrospectively reviewed. Their best-corrected visual acuities in the logarithm of the minimum angle of resolution units and central macular thicknesses were compared at baseline and one month after the final IVF. Eighteen patients and 22 eyes were included and allocated to the naïve and switched groups: 12 cases (15 eyes) and 6 cases (7 eyes), respectively. The best-corrected visual acuity improved for the naïve group, but no difference was observed for the switched group. In contrast, the central macular thickness improved for both the naïve and switched groups. IVF demonstrated good short-term outcomes for DME, suggesting that it is effective for DME in clinical practice.

Indexed as

Diabetic RetinopathyMacular EdemaAgedAntibodies, BispecificFemaleHumansIntravitreal InjectionsMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceTreatment OutcomeVisual AcuityAntibodies, Bispecificfaricimab

Identifiers

PMID40359224
PMCPMC12074261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.