ArticleEmerging infectious diseases2025
Nationwide Implementation of HIV Molecular Cluster Detection by Centers for Disease Control and Prevention and State and Local Health Departments, United States.
Article in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Brief Report: National HIV Molecular Cluster Detection Supports Local Cluster Detection.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Characteristics of HIV Time-Space Alerts in the United States, 2018-2021.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- No Integration Without Preparation: Building Workforce Capacity for Partner Services and HIV Molecular Epidemiology.Open forum infectious diseases · 2026Article
- Advancing Precision Public Health: an implementation science framework for HIV Cluster Detection and Response driven by molecular epidemiology.Frontiers in public health · 2026Article
- A Comprehensive Approach to HIV Cluster Detection and Response: The Role of Partner Services.Sexually transmitted diseases · 2025Article
- HIV-1 and Artificial Intelligence: From Molecular Insight to Population Impact.Journal of AIDS and HIV treatment · 2025Article
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Authors and funding
19 authors.
Funding
Abstract
Detecting and responding to clusters of rapid HIV transmission is a core HIV prevention strategy in the United States, guiding public health interventions and identifying gaps in prevention and care services. In 2016, the Centers for Disease Control and Prevention (CDC) initiated molecular cluster detection using data from 27 jurisdictions. During 2016-2023, CDC expanded sequence reporting nationwide and deployed Secure HIV-TRACE, an application supporting health department (HD) molecular cluster detection. CDC conducts molecular cluster detection quarterly; state and local HDs analyze local data monthly. HDs began routinely reporting clusters to CDC by using cluster report forms in 2020. During 2018-2023, CDC identified 404 molecular clusters of rapid HIV transmission; 325 (80%) involved multiple jurisdictions. During 2020-2023, HDs reported 298 molecular clusters to CDC; 249 were first detected by HDs. Expanding molecular cluster detection has provided a foundation for improving service delivery to networks experiencing rapid HIV transmission.
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Registered trials
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