ArticleProceedings of the National Academy of Sciences of the United States of America2025
CaMK modulates sensory neural activity to control longevity and proteostasis.
Ranran Zhao, Weiqi Ge, Weikang Xue, Zaidong Deng, Jiaze Liu, Kaiqi Wang, Youngnam N Jin, Yanxun V Yu
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Ranran Zhao *Department of Neurology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Weiqi Ge *Department of Nuclear Medicine, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Weikang XueDepartment of Neurology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Zaidong DengDepartment of Neurology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Jiaze LiuDepartment of Neurology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Kaiqi WangDepartment of Neurology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Youngnam N JinDepartment of Nuclear Medicine, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.ORCID 0009-0007-2632-3237 Yanxun V YuDepartment of Neurology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.ORCID 0000-0001-6617-0166 Funding
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MMOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 2042022dx0003MOST | Dream Project of Ministry of Science and Technology of the People's Republic of China (Dream Project of MOST of China) 2021ZD0202603MOST | National Natural Science Foundation of China (NSFC) 32070832MOST | National Natural Science Foundation of China (NSFC) 32150610476NIH HHS P40 OD010440
6 · The paper itselfAbstract
The impact of neural activity on aging and longevity remains poorly understood, with limited understanding of the specific neuron groups and molecular mechanisms that regulate lifespan. In this study, we uncover a correlation between human longevity and reduced CaMK4 expression in the frontal cortex. We further show that this link is conserved in
Indexed as
Calcium-Calmodulin-Dependent Protein Kinase Type 4LongevityProteostasisSensory Receptor CellsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsForkhead Transcription FactorsHumansInsulinCaenorhabditis elegans ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 4daf-16 protein, C elegansForkhead Transcription FactorsInsulinAFD sensory neuronCaM kinaseC. eleganslongevityneuronal activity
Identifiers
PMID40359038
PMCPMC12107105
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