Evidence map›Paper›PMID 40358979›Full record

ArticleCirculation. Cardiovascular quality and outcomes2025

Association of Rurality With Mortality After Congenital Heart Surgery.

Yanxu Yang, Yijian Huang, Jessica H Knight, Matthew E Oster, Lazaros K Kochilas

Registry-linked trialAbstract readMulticenter StudyComparative Study
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07542509 (Digital diagnoSis of Cardiac sOUNd in peDiatric Patients [DI-SOUND Study]), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07542509 recruitingnot on this map

Digital diagnoSis of Cardiac sOUNd in peDiatric Patients [DI-SOUND Study]

TypeobservationalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2024 to 2027Enrolled1,000ConditionsCardiac Disease, Auscultation of Heart, Machine Learning
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yanxu YangDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA (Y.Y., M.E.O., L.K.K.).
Yijian HuangDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health of Emory University, Atlanta, GA (Y.H.).ORCID 0000-0003-4364-3199
Jessica H KnightDepartment of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, GA (J.H.K.).ORCID 0000-0001-5764-7495
Matthew E OsterDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA (Y.Y., M.E.O., L.K.K.).ORCID 0000-0002-2243-8367
Lazaros K KochilasDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA (Y.Y., M.E.O., L.K.K.).ORCID 0000-0002-4686-634X

Funding

Long-term Outcomes after Interventions for Congenital Heart DiseaseR01HL122392 · NHLBI · UNIVERSITY OF MINNESOTA · PI KOCHILAS, LAZAROS K. · 2014 to 2022
$5.2M
NHLBI NIH HHS R01 HL122392
6 · The paper itself

Abstract

backgroundDisparities between metro and nonmetro areas exist in health outcomes. The effect of residing areas on mortality for patients with congenital heart disease remains unclear. We evaluated the relationship of residing areas with survival outcomes after congenital heart surgery (CHS).

methodsThis is a retrospective cohort study of patients enrolled in the Pediatric Cardiac Care Consortium who had a history of CHS. Outcomes were tracked by the National Death Index through 2022. Logistic regression and Cox proportional hazards models were fitted to examine the associations between residence at CHS with in-hospital mortality and long-term survival after adjustment for covariates.

resultsAmong 28 504 eligible patients (47.0% female patients) with a history of CHS, 19 772 (69.4%) patients resided in metro areas. Patients with congenital heart disease living in nonmetro areas at CHS had a lower (86.5%) 30-year survival rate following discharge from initial CHS versus patients living in metro areas (88.4%). After adjustment for sex, birth era, congenital heart disease severity, and presence of chromosomal abnormality, residing in nonmetro areas was associated with an increased risk of long-term mortality (adjusted hazard ratio, 1.12 [95% CI, 1.03-1.21]). Further adjustment for the neighborhood socioeconomic status attenuated the observed reduction in risk of death between nonmetro and metro areas. Patients with mild congenital heart disease who resided in nonmetro and not adjacent to metro areas were independently associated with an increased risk of long-term death (adjusted hazard ratio, 1.34 [95% CI, 1.00-1.77]), after adjustment for covariates and neighborhood socioeconomic status.

conclusionsResidence in nonmetro areas at CHS is associated with an increased risk of death both in the immediate postoperative period in-hospital and on the long-term up to 30 years after CHS discharge, but this association is explained by differential neighborhood socioeconomic status at the time of CHS. These findings provide opportunities for targeted interventions to reduce disparities and improve outcomes for all patients after CHS.

Indexed as

Cardiac Surgical ProceduresHealthcare DisparitiesHealth Status DisparitiesHeart Defects, CongenitalNeighborhood CharacteristicsSocial Determinants of HealthChildChild, PreschoolFemaleHospital MortalityHumansInfantInfant, NewbornMaleRetrospective StudiesRisk Assessmentchildhospitalshumanssocial classsurvival rate

Identifiers

PMID40358979
PMCPMC12173774

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Registered trials

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