Evidence map›Paper›PMID 40358915›Full record

ArticleTranslational stroke research2025

Photobiomodulation Promotes Early Recovery of Olfactory Function and Modulates Neuroprotective Gene Expression in a Mouse Model of Ischemic Stroke.

Reham A Shalaby, Acquah Emmanuel, Fatemeh Dehgan Nezhad, Kohinur Akter, S M Abdus Salam, Jawoon Yi, Sang Seong Kim, Jihwan Park, Hyuk Sang Kwon, Kyung Hwa Lee and 2 more

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Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Reham A ShalabyDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Acquah EmmanuelDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Fatemeh Dehgan NezhadDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Kohinur AkterAI Graduate School, Gwangju Institute of Science and Technology, Gwangju, South Korea.
S M Abdus SalamDepartment of Pathology, Hwasun Hospital and Medical School, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University, Gwangju, South Korea.
Jawoon YiSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Sang Seong KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Jihwan ParkSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Hyuk Sang KwonDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Kyung Hwa LeeDepartment of Pathology, Hwasun Hospital and Medical School, Biomedical Sciences Graduate Program (BMSGP), Chonnam National University, Gwangju, South Korea.
Young Ro KimDepartment of Radiology, Harvard Medical School, Boston, MA, USA. yrkim@mgh.harvard.edu.
Euiheon ChungDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea. ogong50@gist.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke often leads to neurological deficits, including olfactory dysfunction, which can significantly diminish quality of life. Photobiomodulation (PBM) has emerged as a promising therapeutic strategy for enhancing post-stroke recovery, although the molecular mechanisms, particularly regarding gene expression change, are not yet fully understood. This study investigates the long-term effects of photothrombosis (PT) on olfactory function and the olfactory bulb (OB) microenvironment, with a focus on PBM's efficacy during both early and late phases. In a mouse OB PT stroke model, PBM therapy (808-nm laser, 40 J/cm

Indexed as

Ischemic StrokeLow-Level Light TherapyNeuroprotectionRecovery of FunctionSmellAnimalsDisease Models, AnimalGene ExpressionMaleMiceMice, Inbred C57BLOlfactory Bulb

Identifiers

PMID40358915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.