ReviewBiological trace element research2025
A Comprehensive Review of Selenium as a Key Regulator in Thyroid Health.
Review in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of Selenium Exposure During Pregnancy on Risk for Miscarriage: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Recent Advances in the Treatment of Thyroid Pathologies with Selenium-Containing Compounds, Nanoparticles and Nanocomplexes Based on Selenium and Selenoproteins.Biological trace element research · 2026Review
- Selenium, Selenoprotein P, and Gut Dysbiosis are Associated with Cartilage Damage in Osteoarthritis Patients.Biological trace element research · 2026Article
- Trace Elements Dyshomeostasis and Toxic Metals Neurotoxicity in Neurodegenerative Diseases.Biological trace element research · 2026Review
- Dose-dependent effects of selenium (Se)-enriched yeast containing nano-scale Se particles on Se bioavailability, rumen fermentation, hematological profile, and growth performance in female Thin-Tail sheep.Veterinary world · 2026Article
- Selenium Concentration and Speciation in Formulae for Infants: Implications for Infant Health.Foods (Basel, Switzerland) · 2026Article
- Effects of dietary Spirulina powder on production performance, egg quality, antioxidant status, and blood immune-endocrine indices in laying hens.Poultry science · 2026Article
- Comparative Impact of Selenium Selenite and Nano-Selenium on Physiological Functions in Male Goat Kids.Journal of animal physiology and animal nutrition · 2026Article
- Selenoproteins: Minute yet vital players governing cellular fate.Genes & diseases · 2026Review
- Transcriptomic Analysis of Selenium-Induced Antioxidant Responses in Diploid, Triploid, and Tetraploid Pacific Oysters (Foods (Basel, Switzerland) · 2026Article
- A dual-pronged strategy: multi-bioactive nanoplatform synergizes ROS antidote and iron stabilization to protect against liver ischemia-reperfusion injury.Journal of nanobiotechnology · 2026Article
- Effects of Moderately Reduced Dietary Net Energy on Growth Performance, Meat Quality and Intestinal Barrier Function in Growing Pigs.Veterinary sciences · 2026Article
- Strong Antiproliferative Activity Observed in Hammett-Guided Electronic Modulation of GPx-Mimetic Pathways in Aryl Selenoureas.International journal of molecular sciences · 2026Article
- The Role of Selenium in the Antioxidant System of Cattle, Pigs, and Small Ruminants: Implications for Animal Health and Productivity.Animals : an open access journal from MDPI · 2026Review
- The Simultaneous Prevention of Multiple Diseases: A "One Ring to Rule Them All" Framework for Redox-Driven Health and Longevity.Nutrients · 2026Review
- The Impact of Selenium Deficiency and Supplementation on Hashimoto's Thyroiditis: A Clinical Evaluation.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Plant-derived nutritional components in thyroid disease-related neuropsychiatric disorders: mechanistic insights and advances.Frontiers in nutrition · 2026Review
- Thyroid-Microbiome Allostasis and Mitochondrial Performance: An Integrative Perspective in Exercise Physiology.Nutrients · 2025Review
- Comparative Efficacy of Selenium Yeast Supplements on the Health and Productivity of Commercial Layers.Animals : an open access journal from MDPI · 2025Article
- Selenium Nanoparticles as Versatile Delivery Tools.Pharmaceutics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenium (Se) is an essential trace element crucial for thyroid function, participating in the production and metabolism of thyroid hormones and the immune system. It engages in synthesizing selenoproteins, which are essential for antioxidant defense and regulating thyroid hormone levels. It is crucial to convert thyroxine (T4) into the active thyroid hormone triiodothyronine (T3) via deiodinase activity and safeguard thyroid cells from oxidative damage. Therefore, thyroid dysfunction, including abnormalities in thyroid hormone synthesis and the emergence of autoimmune thyroid conditions such as Graves' disease and Hashimoto's thyroiditis, has been linked to Se deficiency. When evaluating the benefits of Se supplementation, it is crucial to recognize that excessive mineral intake may be detrimental and result in adverse consequences, including gastrointestinal disturbances and neurological problems. The effectiveness of Se-based therapies is influenced by individual characteristics, including hereditary anomalies in thyroid function and Se metabolism. Further research should be performed on personalized Se supplementation approaches using genetics and nanotechnology to optimize the bioavailability and efficacy of the supplements. This study aims to thoroughly examine Se's role in thyroid health and how its therapeutic use in thyroid-related diseases may be optimized via appropriate dosing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.