Evidence map›Paper›PMID 40358883›Full record

ArticleDiscover oncology2025

FANCI is involved in the malignant progression of glioma cells by regulating the Akt/Bcl-2 signaling pathway.

Hanyun Li, Yinrui Liu, Mingyao Wang, Shaoshao Xu, Jilan Liu, Xianyun Qin, Banban Li, Jikui Sun, Yan Liu, Feng Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hanyun Li *Cheeloo College of Medicine, Shandong University, Jinan, China.
Yinrui Liu *Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Mingyao WangJining Medical University, Jining, China.
Shaoshao XuCheeloo College of Medicine, Shandong University, Jinan, China.
Jilan LiuDepartment of Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China.
Xianyun QinDepartment of Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, China.
Banban LiDepartment of Hematology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China.
Jikui SunDepartment of Neurosurgery, Huanhu Hospital, Tianjin Medical University, Tianjin, China. jikuisun2015@163.com.
Yan LiuSchool of Public Health, Jining Medical University, Jining, China. hakunaly@163.com.
Feng JinDepartment of Neurosurgery, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, China. jinfengsdjn@163.com.

Funding

China Postdoctoral Science Foundation 2022M711324Key Project of Shandong Provincial Traditional Chinese Medicine Science and Technology Project Z-2022082Natural Science Foundation of Shandong Province ZR2022MH140Project of Scientific Developmental Program of Shandong Provincial Administration of Traditional Chinese Medicine Q-2022136Project of the Key Research and Development Program of Jining Science and Technology 2023YXNS045Shandong First Medical University youth Science Foundation 202201-089Shandong Postdoctoral Science Foundation SDCX-ZG-202303060
6 · The paper itself

Abstract

introductionFanconi anemia supplementation group I (FANCI), one of the Fanconi family proteins, may be closely related to the malignant progression of glioma cells. Here, we sought to validate the expression of FANCI in glioma cells and its role in regulating the Akt signaling pathway in the malignant progression of glioma cells.

methodsThe expression of FANCI in glioma cells was analyzed by bioinformatics and microarray. Lentivirus transfection was used to regulate the expression of FANCI in glioma cells. CCK-8, EdU, Transwell, and flow cytometry were used to observe the effect of FANCI on the malignant progression of glioma cells.

resultsWe found that low expression of FANCI inhibited the proliferation, migration and invasion of human glioma cells, and promoted cell apoptosis. However, overexpression of FANCI produced the opposite effect. We also found that low expression of FANCI inhibited the expression of P-Akt and B-cell lymphoma-2 (Bcl-2). Finally, we validated these in vitro results in a xenograft mouse model.

conclusionFANCI can inhibit the development of glioma by inhibiting Akt/Bcl-2 signaling pathway.

Indexed as

Akt/Bcl-2ApoptosisFANCIGliomaProliferation

Identifiers

PMID40358883
PMCPMC12075725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.