Evidence map›Paper›PMID 40358816›Full record

ArticlePhysical and engineering sciences in medicine2025

Biomechanics-driven dose stress metrics for radiation-induced acute xerostomia prediction among head and neck radiation therapy.

Yusuke Kawazoe, Takehiro Shiinoki, Koya Fujimoto, Yuki Yuasa, Wataru Mukaidani, Yuki Manabe, Miki Kajima, Hidekazu Tanaka

Abstract read
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In one paragraph

Article in Physical and engineering sciences in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yusuke KawazoeDepartment of Radiological Technology, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8535, Japan.
Takehiro ShiinokiDepartment of Radiation Oncology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8535, Japan. shiinoki@yamaguchi-u.ac.jp.ORCID http://orcid.org/0000-0002-0246-8489
Koya FujimotoDepartment of Radiation Oncology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8535, Japan.
Yuki YuasaDepartment of Radiological Technology, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8535, Japan.
Wataru MukaidaniDepartment of Radiological Technology, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8535, Japan.
Yuki ManabeDepartment of Radiation Oncology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8535, Japan.
Miki KajimaDepartment of Radiation Oncology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8535, Japan.
Hidekazu TanakaDepartment of Radiation Oncology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8535, Japan.

Funding

Japan Society for the Promotion of Science 20K16789Japan Society for the Promotion of Science 22K07667Japan Society for the Promotion of Science 25K19140Takeda Science Foundation Takeda Science Foundation
6 · The paper itself

Abstract

Xerostomia is a condition commonly affecting patients subjected to radiation therapy (RT) for head and neck cancer (HNC) treatment. We propose dose metrics that consider the stress of parotid glands (PGs) during RT by using finite element analysis (FEA) of structural changes captured via computed tomography (CT) images acquired before and during RT to evaluate their effectiveness in predicting acute xerostomia. Thirty patients treated for HNC via in volumetric modulated arc therapy were enrolled. Patient complaints were considered by radiation oncologists based on the common terminology criteria for adverse events and scored as xerostomia grade 0 (XG-0), XG-1, or XG-2. All patients underwent CT both before and during RT (CT

Indexed as

Head and Neck NeoplasmsStress, MechanicalXerostomiaAcute DiseaseAdultAgedBiomechanical PhenomenaDose-Response Relationship, RadiationFemaleFinite Element AnalysisHumansMaleMiddle AgedParotid GlandRadiotherapy DosageRadiotherapy, Intensity-ModulatedFinite element analysisRadiation therapyStress mapXerostomia

Identifiers

PMID40358816

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.