ArticleJournal of neuro-oncology2025
Predictors of return to work following surgery in patients with glioblastoma: a retrospective multicenter study.
Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWhile clinical outcomes of glioblastoma (GBM) are well-documented, its socio-economic impact, particularly on return to work (RTW) remains unexplored. In this study we aimed to identify the predictors of RTW at 6 months postoperatively in patients undergoing GBM treatment and to assess its association with post-operative neurological deficits and median overall survival (mOS).
methodsWe retrospectively studied 106 adults with pre-operative employment, undergoing primary GBM resection or biopsy at three tertiary centers. RTW at 3 and 6 months postoperatively were assessed using univariate and multivariate analyses.
resultsAfter 6 months 33 patients (33.1%) were able to RTW. Factors associated with lower odds of RTW included female sex (p = 0.039), Karnofsky Performance Scale (KPS) < 80 at 2 weeks (p = 0.034), and 3 months post-operatively (p = 0.0001), right handedness (p = 0.038), and subtotal resection (p = 0.042). On multivariate analysis female sex (OR 0.238, 95% CI 0.077-0.733, p = 0.012) and three-month postoperative KPS < 80 (OR 0.019, 95% CI 0.001-0.0293, p = 0.004) were the least likely to RTW at six months. Acute postoperative motor (p = 0.047), gait (p = 0.008) and cognitive deficits (p = 0.048) and persistent motor (p = 0.017), gait (p = 0.033) and language (p = 0.026) deficits were all associated with lesser RTW. Patients who returned to work had significantly longer mOS (21.44, p < 0.001).
conclusionsRTW at 6 months post GBM Surgery corelates with improved mOS. Female sex and lower post-operative KPS scores were the strongest predictors of reduced RTW.
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