ArticleArchives of osteoporosis2025
Bone microarchitecture using HR-pQCT in adult patients with renal tubular acidosis presenting with rickets/osteomalacia.
Article in Archives of osteoporosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adults with renal tubular acidosis (RTA) show high bone turnover, reduced trabecular volumetric bone mineral density (vBMD), and compromised bone microarchitecture, especially in trabecular bone. HR-pQCT analysis reveals lower total vBMD, reduced trabecular number, increased separation, and cortical thinning, highlighting bone deterioration in RTA patients compared to controls.
backgroundRenal tubular acidosis (RTA) impairs urinary acidification, leading to a normal anion gap metabolic acidosis and often hypokalemia. RTA can result in poor bone mineralization and reduced bone density in adults. This study aims to evaluate bone microarchitecture in adults with RTA using second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT).
methodsIn this cross-sectional case-control study, 12 adult RTA patients with rickets/osteomalacia and 12 age, sex, and BMI-matched controls were enrolled. Clinical assessments, biochemical tests with calcium, phosphate, alkaline phosphatase, 25(OH)D, intact PTH, bone turnover markers, dual-energy X-ray absorptiometry (DXA), and HR-pQCT scans were conducted.
resultsPatients with RTA had increased bone turnover compared to the controls. RTA patients had significantly lower total hip areal bone mineral density (aBMD) [g/cm
conclusionAdults with RTA exhibit high bone turnover, reduced trabecular vBMD, and compromised bone microarchitecture, particularly in trabecular bone.
Indexed as
Identifiers
40358759What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.