ArticleDie Ophthalmologie2025
[Patient- and donor-dependent factors in descemet membrane endothelial keratoplasty and their impact on visual acuity and quality of life].
Article in Die Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDescemet membrane endothelial keratoplasty (DMEK) is the gold standard for the treatment of endothelial corneal decompensation. The rapid postoperative improvement in visual acuity and the lower rejection rate of this minimally invasive procedure compared to penetrating keratoplasty justify the high acceptance of DMEK.
objectiveThe aim of this study was to analyse the general conditions for an optimal visual outcome after DMEK by recording patient- and graft-dependent factors. STUDY DESIGN AND
methodsA total of 72 eyes were retrospectively analysed in which Fuchs' endothelial dystrophy was treated by DMEK at the University Eye Hospital in Halle in 2019 and 2020. The data at the following timepoints were collected: preoperative graft examination, examination prior to surgery and one examination within the first 6 months postoperatively and one in the second postoperative year. In particular, the best corrected visual acuity (BCVA) and endothelial cell density were compared. A patient survey was used to evaluate the subjectively perceived success of the therapy. The main focus was on reduction in symptoms and the regained independence and participation in social life.
resultsThe BCVA increased from 0.37 ± 0.15 (logMAR 0.43 ± 0.82) preoperatively to 0.65 ± 0.18 (logMAR 0.19 ± 0.74) in the second postoperative year. The endothelial cell density of the transplant decreased from 2503 ± 206 cells/mm
conclusionDMEK is an effective and safe procedure. The visual outcome can be influenced by various patient- and graft-dependent factors. Patients who had previously undergone other eye operations or had other eye diseases achieved a lower average postoperative increase in visual acuity. In addition, a correlation between donor gender and the decrease in endothelial cell density can be recognised. The endothelial cell loss in female donors is greater than in male donors.
Indexed as
Identifiers
40358733What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.