Evidence map›Paper›PMID 40358730›Full record

ArticleSkeletal radiology2025

Exact radiological-pathological correlation of chondrosarcomas using a patient-specific 3D mold.

Maryse Lejoly, Thomas Van Den Berghe, David Creytens, Wouter Huysse, Gwen Sys, Renaat Coopman, Koenraad L Verstraete

Abstract read
PubMed Publisher
In one paragraph

Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maryse LejolyDepartment of Radiology and Medical Imaging, Ghent University Hospital, -1K12 / Entrance 12 Route 1590, Corneel Heymanslaan 10, B-9000, Ghent, Belgium. maryse.lejoly@gmail.com.ORCID http://orcid.org/0000-0002-1151-3966
Thomas Van Den BergheDepartment of Radiology and Medical Imaging, Ghent University Hospital, -1K12 / Entrance 12 Route 1590, Corneel Heymanslaan 10, B-9000, Ghent, Belgium.
David CreytensDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Wouter HuysseDepartment of Radiology and Medical Imaging, Ghent University Hospital, -1K12 / Entrance 12 Route 1590, Corneel Heymanslaan 10, B-9000, Ghent, Belgium.
Gwen SysDepartment of Orthopaedic Surgery and Traumatology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Renaat CoopmanDepartment of Plastic, Reconstructive and Aesthetic Surgery, Ghent University Hospital, Ghent, Belgium.
Koenraad L VerstraeteDepartment of Radiology and Medical Imaging, Ghent University Hospital, -1K12 / Entrance 12 Route 1590, Corneel Heymanslaan 10, B-9000, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify aggressive regions in high-grade and dedifferentiated chondrosarcomas on MRI by obtaining an exact correlation between radiology and histopathology. MATERIALS AND

methodsOne chondrosarcoma grade II (CSII), chondrosarcoma grade III (CSIII) and dedifferentiated chondrosarcoma (DDCS) were segmented on (DCE-)MRI images. Around the segmentations, a patient specific mold was constructed and 3D-printed with cutting grooves perfectly aligned with selected MRI slices. In this way, resection specimens could be cut at the same locations as the MRI slices. Histopathology slides were stained with hematoxylin-eosin and CD31 (vascularization) and correlated with the (DCE-)MRI. Histopathologically, atypical cartilaginous tumor (ACT), CSII, CSIII and DDCS regions were delineated and vascular hotspots were selected by an experienced pathologist. Exact point-to-point correlation was performed.

resultsACT, CSII, CSIII and DDCS regions all had similar mean signal intensity on T1-weighted images. On fat-saturated T2-weigthed images, CSII and CSIII regions had a higher mean signal intensity. On fat-saturated T1-weighted images after gadolinium contrast injection and on wash-in parametric maps DDCS regions had the highest mean signal intensity and highest wash-in values. There was a higher microvessel density in CSII and CSIII regions. This corresponded with a thick enhancing rim on fat-saturated T1-weighted images after gadolinium contrast injection and with a higher wash-in.

conclusionThis new 3D mold helps to identify high-grade chondrosarcoma regions with myxoid. This may be useful for targeted biopsy and histopathological investigation.

Indexed as

Bone NeoplasmsChondrosarcomaMagnetic Resonance ImagingPrinting, Three-DimensionalAdultAgedContrast MediaFemaleHumansMaleMiddle AgedNeoplasm GradingContrast Media(DCE-)MRIDedifferentiated chondrosarcomaHigh-grade chondrosarcomaHistopathologyMicrovessel densityMoldingPoint-to-point correlationVascularizationWash-in

Identifiers

PMID40358730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.