Evidence map›Paper›PMID 40358668›Full record

ArticleJournal of youth and adolescence2025

Independent, Multiplicative, and Cumulative Effects of Recent Stressful Life Events and Adverse Childhood Events on Depressive Symptoms among College Students: Moderation by the HPA-axis Multilocus Genetic Variation.

Yang Yang, Chunyu Liu, Pian Chen, Shan Sun, Hongmei Zhang, Meiping Wang, Wenxin Zhang

Abstract read
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In one paragraph

Article in Journal of youth and adolescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang YangDepartment of Psychology, Shandong Normal University, Jinan, China.
Chunyu LiuDepartment of Student Affairs Management, Yantai University, Yantai, China.
Pian ChenDepartment of Psychology, Shandong Normal University, Jinan, China.
Shan SunDepartment of Psychology, Shandong Normal University, Jinan, China.
Hongmei ZhangDepartment of Psychology, Shandong Normal University, Jinan, China.
Meiping WangDepartment of Psychology, Shandong Normal University, Jinan, China. wangmeiping@sdnu.edu.cn.
Wenxin ZhangDepartment of Psychology, Shandong Normal University, Jinan, China.

Funding

National Social Science Fund of China 21BSH101Natural Science Foundation of Shandong Province ZR2021MC121
6 · The paper itself

Abstract

Previous research has explored the effects of early and recent stress on depressive symptoms, yielding meaningful findings. However, no research has yet comprehensively verified and compared the independent, multiplicative (interactive), and cumulative (additive) effects of these stresses on depressive symptoms. Consequently, the mechanisms by which early and recent stress contribute to depressive symptoms, as well as the extent of individual differences in these processes, remain poorly understood. This study aimed to address this gap by simultaneously examining the independent, multiplicative, and cumulative effects of recent stressful life events and adverse childhood events on depressive symptoms in late adolescence. Additionally, it investigated the moderating role of multilocus genetic variations related to the hypothalamic-pituitary-adrenal (HPA) axis within these models. A theory-driven multilocus genetic profile score (MGPS) was calculated using FKBP5 rs1360780, NR3C1 rs41423247, and CRHR1 rs110402 polymorphisms. The study recruited a sample of 1227 adolescents (M

Indexed as

Adverse Childhood ExperiencesDepressionHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemStress, PsychologicalStudentsAdolescentCRF Receptor, Type 1FemaleGenetic VariationHumansLife Change EventsMaleReceptors, Corticotropin-Releasing HormoneReceptors, GlucocorticoidTacrolimus Binding Protein 5CRF Receptor, Type 1NR3C1 protein, humanReceptors, Corticotropin-Releasing HormoneReceptors, GlucocorticoidTacrolimus Binding Protein 5Tacrolimus Binding ProteinsAdverse childhood eventsCollege studentsDepressive symptomsHPA-axis geneticsRecent stressful life events

Identifiers

PMID40358668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.