Evidence map›Paper›PMID 40358461›Full record

ArticleChemistry, an Asian journal2025

Visible Light-Mediated Preparation of a Key Intermediate Employed in the Synthesis of Zolpidem and Several Analogs.

Ronei M S Souza, Tales A C Goulart, Roberto do C Pinheiro, Felipe F do C Sonaglio, Deborah de A Simoni, Rodrigo A Cormanich, Igor D Jurberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry, an Asian journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ronei M S SouzaDepartment of Organic Chemistry, Institute of Chemistry, State University of Campinas, Rua Monteiro Lobato 270, 13083-862, Campinas, SP, Brazil.
Tales A C GoulartDepartment of Organic Chemistry, Institute of Chemistry, State University of Campinas, Rua Monteiro Lobato 270, 13083-862, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0002-1124-8824
Roberto do C PinheiroDepartment of Organic Chemistry, Institute of Chemistry, State University of Campinas, Rua Monteiro Lobato 270, 13083-862, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0002-2281-3219
Felipe F do C SonaglioDepartment of Organic Chemistry, Institute of Chemistry, State University of Campinas, Rua Monteiro Lobato 270, 13083-862, Campinas, SP, Brazil.
Deborah de A SimoniInstitutional X-Ray Laboratory, Institute of Chemistry, State University of Campinas, Rua Monteiro Lobato 270, 13083-862, Campinas, SP, Brazil.
Rodrigo A CormanichDepartment of Organic Chemistry, Institute of Chemistry, State University of Campinas, Rua Monteiro Lobato 270, 13083-862, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0001-7659-1749
Igor D JurbergDepartment of Organic Chemistry, Institute of Chemistry, State University of Campinas, Rua Monteiro Lobato 270, 13083-862, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0002-1133-6277

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/03910-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/01104-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/01750-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/11152-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/12360-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/13198-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/07611-7
6 · The paper itself

Abstract

This work describes a protocol being only promoted by visible light for the C3-alkylation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines with aryldiazoacetates. Several known and new analogs of a key intermediate employed in previous syntheses of zolpidem have been accessed in good yields. The preparation of this key intermediate was also achieved using this method, but an adjustment of the nature of the alkylating agent was required.

Indexed as

Diazo compoundImidazo[1,2‐a]pyridineImidazo[1,2‐a]pyrimidineVisible lightZolpidem

Identifiers

PMID40358461
PMCPMC12392708

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.