Evidence map›Paper›PMID 40358450›Full record

ArticleRadiology2025

Radiomic Parenchymal Phenotypes of Breast Texture from Mammography and Association with Risk of Breast Cancer.

Stacey J Winham, Anne Marie McCarthy, Christopher G Scott, Aimilia Gastounioti, Hannah Horng, Aaron D Norman, Walter C Mankowski, Lauren Pantalone, Matthew R Jensen, Raymond J Acciavatti and 7 more

Abstract read
In one paragraph

Article in Radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Stacey J WinhamDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Biobusiness Bldg 5-81, Rochester, MN 55905.ORCID 0000-0002-8492-9102
Anne Marie McCarthyDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pa.
Christopher G ScottDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Biobusiness Bldg 5-81, Rochester, MN 55905.ORCID 0000-0003-1340-0647
Aimilia GastouniotiDepartment of Radiology, Washington University in St Louis, St Louis, Mo.ORCID 0000-0002-3359-7195
Hannah HorngDepartment of Radiology, University of Pennsylvania, Philadelphia, Pa.ORCID 0000-0002-8632-9426
Aaron D NormanDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Biobusiness Bldg 5-81, Rochester, MN 55905.ORCID 0000-0002-4208-2708
Walter C MankowskiDepartment of Radiology, University of Pennsylvania, Philadelphia, Pa.ORCID 0000-0001-8591-6592
Lauren PantaloneDepartment of Radiology, University of Pennsylvania, Philadelphia, Pa.
Matthew R JensenDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Biobusiness Bldg 5-81, Rochester, MN 55905.ORCID 0009-0005-0721-9296
Raymond J AcciavattiDepartment of Radiology, University of Pennsylvania, Philadelphia, Pa.ORCID 0000-0003-4822-3353
Andrew D A MaidmentDepartment of Radiology, University of Pennsylvania, Philadelphia, Pa.ORCID 0000-0003-1074-7063
Eric A CohenDepartment of Radiology, University of Pennsylvania, Philadelphia, Pa.
Kathleen R BrandtDepartment of Radiology, Mayo Clinic, Rochester, Minn.ORCID 0000-0003-2144-261X
Emily F ConantDepartment of Radiology, University of Pennsylvania, Philadelphia, Pa.ORCID 0000-0001-9331-644X
Karla M Kerlikowske *Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif.ORCID 0000-0001-8793-8779
Despina Kontos *Department of Radiology, University of Pennsylvania, Philadelphia, Pa.ORCID 0000-0001-9031-5126
Celine M Vachon *Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Biobusiness Bldg 5-81, Rochester, MN 55905.ORCID 0000-0002-1962-9322

Funding

Risk-based Imaging Strategies to Improve Breast Cancer Surveillance OutcomesP01CA154292 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KARLA M KERLIKOWSKE · 2011 to 2026
$52.9M
Effect of Breast Density on Screening Recall with Digital Breast TomosynthesisR01CA161749 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KONTOS, DESPINA · 2012 to 2021
$3.6M
Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detectionR01CA207084 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, KONTOS, DESPINA · 2017 to 2021
$3.2M
Advancing breast cancer risk assessment with digital breast tomosynthesisR01CA286120 · NCI · WASHINGTON UNIVERSITY · PI Aimilia Gastounioti · 2024 to 2026
$3.1M
Automated Density Measures for Estimating Breast Cancer Risk and Therapy ResponseR01CA177150 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, VACHON, CELINE M · 2013 to 2017
$3.0M
NCI NIH HHS P01 CA154292NCI NIH HHS R01 CA161749NCI NIH HHS R01 CA177150NCI NIH HHS R01 CA207084NCI NIH HHS R01 CA286120
6 · The paper itself

Abstract

Background Parenchymal phenotypes reflect the intrinsic heterogeneity of both tissue structure and distribution on mammograms. Purpose To define parenchymal phenotypes on the basis of radiomic texture features derived from full-field digital mammography (FFDM) in breast screening populations and assess associations of parenchymal phenotypes with future risk of breast cancer and masking (false-negative [FN] findings or interval cancers), beyond breast density, and by race and ethnicity Materials and Methods A two-stage study design included a retrospective cross-sectional study of 30 000 randomly selected women with four-view FFDM (mean age, 57.4 years) and a nested case-control study of 1055 women with invasive breast cancer (151 Black and 893 White women) matched to 2764 women without breast cancer (411 Black and 2345 White women) (mean age, 60.4 years) sampled from April 2008 to September 2019 from three diverse breast screening practices. Radiomic features (

Indexed as

Breast NeoplasmsMammographyAdultAgedBreastBreast DensityCase-Control StudiesCross-Sectional StudiesFemaleHumansMiddle AgedPhenotypeRadiomicsRetrospective StudiesRisk Factors

Identifiers

PMID40358450
PMCPMC12127954

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.