Evidence map›Paper›PMID 40358420›Full record

ReviewAnnals of human genetics2025

Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes.

John Henry McDermott, Videha Sharma, Jessica Keen, William Gerard Newman

Abstract readReview
In one paragraph

Review in Annals of human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John Henry McDermottDivision of Evolution, Infection and Genomics, School of Biological Sciences, University of Manchester, Manchester, UK.ORCID 0000-0002-5220-8837
Videha SharmaCentre for Health Informatics, Division of Informatics, Imaging and Data Science, University of Manchester, Manchester, UK.ORCID 0000-0001-7640-1239
Jessica KeenManchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK.ORCID 0009-0009-7708-8534
William Gerard NewmanDivision of Evolution, Infection and Genomics, School of Biological Sciences, University of Manchester, Manchester, UK.ORCID 0000-0002-6382-4678

Funding

Innovate UK 10058536the Manchester NIHR Biomedical Research Centre BRC NIHR 203956
6 · The paper itself

Abstract

Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug-gene associations. Here, we describe the current reactive model of single gene testing and the potential for this to change to a pre-emptive panel or genome-based approach. For this change to occur, three major challenges need to be addressed-the pharmacogenomic testing approach, the digital and data integration, and service delivery models. We explore some of the potential solutions and how pharmacogenomics can be integrated into routine care at scale for patient benefit.

Indexed as

PharmacogeneticsPharmacogenomic TestingHumansPrecision Medicineadoptionadverse drug reactiondrug optimisationeffectivenessimplementationpharmacogenomics

Identifiers

PMID40358420
PMCPMC12336961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.