Evidence map›Paper›PMID 40358209›Full record

ArticleJournal of virology2025

Binding antibody titers against the hemagglutinin and neuraminidase correlate with protection against medically attended influenza A and B disease.

Marios Koutsakos, Arnold Reynaldi, Malet Aban, Ian G Barr, David S Khoury, Miles P Davenport, Ali H Ellebedy, Philip A Mudd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marios KoutsakosDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0001-9994-9723
Arnold ReynaldiKirby Institute, University of New South Wales, Kensington, New South Wales, Australia.
Malet AbanWHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Ian G BarrDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
David S KhouryKirby Institute, University of New South Wales, Kensington, New South Wales, Australia.ORCID 0000-0002-2663-1551
Miles P DavenportKirby Institute, University of New South Wales, Kensington, New South Wales, Australia.
Ali H EllebedyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Philip A MuddCenter for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, Missouri, USA.

Funding

Household Respiratory Virus SARS-CoV-2 Transmission and Immunity Sub-Study (HRTS)U01AI144616 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GORDON, AUBREE L, THOMAS, PAUL G. · 2019 to 2025
$43.7M
DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSESU01AI150747 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, ANTIA, RUSTOM NOSHIR · 2020 to 2024
$5.9M
Programming Durable Immune Responses To VaccinationU01AI141990 · NIAID · WASHINGTON UNIVERSITY · PI Ali Hassan Ellebedy · 2019 to 2026
$5.3M
Structural interrogation of vaccine- and infection-induced B cell responsesR01AI168178 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Goran Bajic · 2022 to 2026
$3.9M
Unraveling Human T Follicular Helper Cell DevelopmentR01AI173203 · NIAID · WASHINGTON UNIVERSITY · PI Philip A Mudd · 2023 to 2026
$2.5M
NIAID NIH HHS R01 AI168178NIAID NIH HHS R01 AI173203NIAID NIH HHS U01 AI141990NIAID NIH HHS U01 AI144616NIAID NIH HHS U01 AI150747
6 · The paper itself

Abstract

Human challenge and cohort studies have identified various correlates of protection (CoP) against influenza A and B viruses (IAV/IBV). However, associations with viral load, investigation of mucosal CoPs, and CoPs against IBV are limited in the context of natural infections. Plasma and nasal swabs were collected (2017-2020) from 56 adults diagnosed with IAV (

Indexed as

Antibodies, ViralHemagglutinin Glycoproteins, Influenza VirusInfluenza B virusInfluenza, HumanNeuraminidaseViral ProteinsAdultAgedFemaleHumansImmunoglobulin AInfluenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeMaleMiddle AgedAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusImmunoglobulin ANeuraminidaseViral Proteinsantibodycorrelates of protectionhemagglutinininfluenzaneuraminidase

Identifiers

PMID40358209
PMCPMC12172496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.