Evidence map›Paper›PMID 40358188›Full record

ArticleCells2025

RBFOX1 Regulates Calcium Signaling and Enhances SERCA2 Translation.

Sadiq Umar, Wuqiang Zhu, Fernando Souza-Neto, Ingrid Bender, Steven C Wu, Chastity L Healy, Timothy D O'Connell, Jop H van Berlo

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sadiq UmarLillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-4733-5751
Wuqiang ZhuLillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-5217-7789
Fernando Souza-NetoLillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Ingrid BenderLillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Steven C WuDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-0864-0208
Chastity L HealyDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Timothy D O'ConnellDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA.
Jop H van BerloLillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9229-4429

Funding

Cardiomyocyte Non-autonomous Factors and Cardiac Regeneration in Large MammalsR01HL156855 · NHLBI · MAYO CLINIC ARIZONA · PI Wuqiang Zhu · 2022 to 2026
$3.3M
Immune Mechanisms Regulating Cardiac RemodelingR01HL155993 · NHLBI · UNIVERSITY OF MINNESOTA · PI REVELO, XAVIER, VAN BERLO, JOHANNES (JOP) · 2021 to 2024
$2.9M
Strategies to Enhance Engineered Heart Tissue Based Myocardial RepairR01HL162747 · NHLBI · MAYO CLINIC ARIZONA · PI Jingwei Xie, Wuqiang Zhu · 2023 to 2026
$2.9M
Computational and Experimental Modeling of Cardiomyocyte ProliferationR01HL160665 · NHLBI · UNIVERSITY OF VIRGINIA · PI SAUCERMAN, JEFFREY J., VAN BERLO, JOHANNES (JOP) · 2022 to 2025
$2.8M
Electrically Conductive Stem Cell Derived MicroEngineered Heart Tissue for Regeneration of Injured MyocardiumR01HL172784 · NHLBI · MAYO CLINIC ARIZONA · PI Mehdi Nikkhah, Wuqiang Zhu · 2024 to 2026
$2.0M
Strategic activation of endogenous c-kit+ progenitor cells for cardiac regenerationR01HL130072 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2016 to 2020
$1.9M
Myocardial Repair with a Novel Engineered Cardiac Muscle PatchR01HL142627 · NHLBI · MAYO CLINIC ARIZONA · PI ZHU, WUQIANG · 2019 to 2022
$1.7M
NHLBI NIH HHS R01 HL130072NHLBI NIH HHS R01 HL142627NHLBI NIH HHS R01 HL155993NHLBI NIH HHS R01 HL156855NHLBI NIH HHS R01 HL160665NHLBI NIH HHS R01 HL162747NHLBI NIH HHS R01 HL172784NIH HHS R01HL130072, R01HL155993, R01HL160665
6 · The paper itself

Abstract

RBFOX1 is an RNA-binding protein that regulates alternative splicing and RNA processing in the neurons, skeletal muscle, and heart. We intended to define the role of RBFOX1 in regulating calcium homeostasis to maintain normal cardiac function. We generated cardiomyocyte-specific

Indexed as

Calcium SignalingProtein BiosynthesisRNA Splicing FactorsSarcoplasmic Reticulum Calcium-Transporting ATPasesAnimalsCalciumCardiomegalyMaleMiceMice, KnockoutMyocytes, CardiacRNA, MessengerSarcoplasmic ReticulumAtp2a2 protein, mouseCalciumRbfox1 protein, mouseRNA, MessengerRNA Splicing FactorsSarcoplasmic Reticulum Calcium-Transporting ATPasescalcium signalingcardiac hypertrophygene regulationheart failure

Identifiers

PMID40358188
PMCPMC12072054

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.