ArticleAlzheimer disease and associated disorders
Cortical Thickness Predictors of Performance-Based Functional Task Variability in the Alzheimer Disease Spectrum.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Performance-Based Functional Status Predicts Diffuse Cortical Atrophy in Alzheimer's Disease.Brain sciences · 2026Article
- Most Neuroscience Data Is Not Normally Distributed: Analyzing Your Data in a Non-normal World.eNeuro · 2026Article
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7 authors.
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Abstract
purposeDetermine whether regional measures of cortical thickness are associated with functional task performance. PATIENTS: One hundred six older adults who were classified as either cognitively unimpaired (CU), mild cognitive impairment (MCI), or Alzheimer disease (AD) completed a performance-based functional task.
methodsThe SD of completion times of 6 consecutive trials within a session of the functional task was used as the primary measure for each participant, reflecting intraindividual variability. Regression tree analysis identified cortical gray matter thickness measures that best predicted intraindividual variability on the functional task.
resultsCortical thickness measures from temporal, parietal, frontal, and occipital regions best predicted intraindividual variability on the task, which are cortical regions associated with learning, executive function, and visuospatial function. Specifically, the fusiform gyrus was featured prominently in these and prior regression tree results, suggesting its possible involvement in this behavioral task.
conclusionThese analyses suggest a mechanistic focus of variability on this functional task, which could serve as an outcome in clinical trials.
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