ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Use of Wearable Technology for Measuring and Characterizing Sedentary Behavior in People With Mild Cognitive Impairment and Dementia: Systematic Review.JMIR aging · 2026Pooled it
- Pooled it
- Arterial Spin Labeling Hemodynamic Indices Relate to Cognitive and Small Vessel Disease Trajectories Over 11 Years.Stroke · 2026Article
- Cognitively engaging sedentary activities are associated with better cognitive function in middle-aged adults: a cross-sectional study using the 1970 British Cohort Study.Journal of activity, sedentary and sleep behaviors · 2026Article
- Lower cardiac output is a risk factor for faster cerebral atrophy over a 11-year follow-up period in APOE-ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The role of depression in the association between handgrip strength and mild cognitive impairment among Chinese older adults.BMC geriatrics · 2026Article
- Association Between Prolonged Sedentary Time and Elevated High-sensitivity C-reactive Protein Among Korean Adults Aged 65 Years or Older: KNHANES 2022.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Article
- Development of an mHealth Intervention for Reducing Sedentary Behavior in Older Adults: Delphi Study.Journal of medical Internet research · 2026Article
- High-fat diet is associated with accelerated gray matter atrophy in cognitively unimpaired older adults but slower atrophy in individuals with existing mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Article
- The associations between sedentary behavior and cognition in a population cohort of older adults.Journal of Alzheimer's disease : JAD · 2026Article
- Association of 24-hour movement guideline adherence with inhibitory control in older adults: the mediating role of general self-efficacy.Frontiers in psychology · 2026Article
- Effect of organismal rhythmic activity on Aβ clearance by the glymphatic system.European journal of medical research · 2025Review
- Recent drinking in alcohol use disorder as a modifiable risk factor of postural tremor and instability in mild cognitive impairment: An initial study.Alcohol, clinical & experimental research · 2025Article
- Global burden, spatiotemporal disparities, and sex-specific trends of early- and late-onset Alzheimer's disease and other dementias: a comparative analysis and projections to 2035.BMC neurology · 2025Article
- Applying the Human-Centered Innovation Biodesign Framework to the Development and Piloting of a Program to Mitigate Risk for Cognitive Decline Among Historically Underrepresented Individuals: Case Study.JMIR formative research · 2025Article
- Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Mitochondrial blood-based biomarker is related to cardiorespiratory fitness and aging in a sex-dependent manner.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
introductionSedentary behavior may be a modifiable risk factor for Alzheimer's disease (AD). We examined how sedentary behavior relates to longitudinal brain structure and cognitive changes in older adults.
methodsVanderbilt Memory and Aging Project participants (n = 404) completed actigraphy (7 days), neuropsychological assessment, and 3T brain MRI over a 7-year period. Cross-sectional and longitudinal linear regressions examined sedentary time in relation to brain structure and cognition. Models were repeated testing for effect modification by apolipoprotein E (APOE) ε4 status.
resultsIn cross-sectional models, greater sedentary time related to a smaller AD-neuroimaging signature (β = -0.0001, p = 0.01) and worse episodic memory (β = -0.001, p = 0.003). Associations differed by APOE-ε4 status. In longitudinal models, greater sedentary time related to faster hippocampal volume reductions (β = -0.1, p = 0.008) and declines in naming (β = -0.001, p = 0.03) and processing speed (β = -0.003, p = 0.02; β = 0.01, p = 0.01). DISCUSSION: Results support the importance of reducing sedentary time, particularly among aging adults at genetic risk for AD. HIGHLIGHTS: Greater sedentary behavior is related to neurodegeneration and worse cognition. Associations differed by APOE-ε4 carrier status in cross-sectional models. Sedentary behavior is an independent risk factor for Alzheimer's disease.
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