Evidence map›Paper›PMID 40357842›Full record

ArticleEpileptic disorders : international epilepsy journal with videotape2025

Effect of stereo-EEG versus subdural EEG on functional and seizure outcome in pediatric and adult epilepsy surgery: A 21-year single-center experience.

Ahmed Gaballa, Christian G Bien, Philip Grewe, Anne Hagemann, Thilo Kalbhenn, Tilman Polster, Friedrich G Woermann, Thomas Cloppenborg

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Epileptic disorders : international epilepsy journal with videotape, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Beyond Broca and Wernicke: Epilepsy surgery in the language areas.Epileptic disorders : international epilepsy journal with videotape · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmed GaballaDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Centre, Medical School OWL, Bielefeld University, Bielefeld, Germany.ORCID https://orcid.org/0009-0002-3929-4686
Christian G BienDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Centre, Medical School OWL, Bielefeld University, Bielefeld, Germany.ORCID https://orcid.org/0000-0003-2225-8654
Philip GreweClinical Neuropsychology, Medical School OWL, Bielefeld University, Bielefeld, Germany.
Anne HagemannSociety for Epilepsy Research, Bielefeld, Germany.
Thilo KalbhennDepartment of Neurosurgery (Evangelisches Klinikum Bethel), Medical School OWL, Bielefeld University, Bielefeld, Germany.ORCID https://orcid.org/0000-0001-6249-629X
Tilman PolsterDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Centre, Medical School OWL, Bielefeld University, Bielefeld, Germany.
Friedrich G WoermannDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Centre, Medical School OWL, Bielefeld University, Bielefeld, Germany.
Thomas CloppenborgDepartment of Epileptology, Krankenhaus Mara, Bethel Epilepsy Centre, Medical School OWL, Bielefeld University, Bielefeld, Germany.ORCID https://orcid.org/0000-0002-6688-6575

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective(1) To compare use, benefits, and complications of stereo-EEG (SEEG) and subdural EEG (SD) in presurgical epilepsy candidates. (2) To evaluate the effectiveness of both methods in delineation of the epileptogenic zone (EZ) and guiding tailored resective surgery.

methodsWe included patients with SEEG or SD evaluations in children and adults at the Bethel Epilepsy Centre, Germany, between 2000 and 2020. We retrospectively assessed epilepsy related parameters, main indication of iEEG (intracranial EEG, for identification of the EZ and functional mapping), complications, seizure, and functional outcome. The second objective was addressed by a subgroup analysis in patients with focal cortical dysplasia (FCD) and mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) for delineation of the EZ.

resultsTwo hundred and nineteen iEEG explorations in 215 patients (age range: 1.3-64.6 years) were assessed (SEEG, n = 78; SD, n = 141). We observed a change in iEEG usage away from SD towards SEEG. In the SEEG group, the decision rate against surgery was higher (SEEG: 23.1% vs. SE: 3.5%, p < .001) and more patients achieved seizure freedom 2 years after surgery (SEEG: 67.8% vs. SD: 46.5%, p = .008). For all iEEG, complications were rare; symptomatic intracranial bleeding only occurred in the SD group (n = 6, 4.3%). In patients with FCD/MOGHE for delineation of the EZ, all patients were operated with favorable seizure freedom after SEEG, but with acceptance of planned neurological deficits (SEEG n = 8, SD n = 20, seizure freedom rate SEEG 87.5% vs. SD 30%, p = .011; neurological deficits: SEEG n = 3 planned motor deficits vs. SD n = 1 unplanned motor deficit due to ischemia). SIGNIFICANCE: SEEG has largely replaced SD in iEEG for the identification of the EZ. It is better tolerated and allows more freedom of choice with respect to resective surgery, resulting in the better identification of surgical candidates and delineation of the EZ with favorable seizure outcomes.

Indexed as

ElectrocorticographyElectroencephalographyEpilepsyNeurosurgical ProceduresSeizuresAdolescentAdultChildChild, PreschoolFemaleHumansInfantMaleMalformations of Cortical DevelopmentMiddle AgedRetrospective Studiesepilepsy surgeryintracranial EEGSEEGsubdural EEG

Identifiers

PMID40357842
PMCPMC12398195

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.