ArticleActa orthopaedica et traumatologica turcica2025
The dose-dependent effect of tranexamic acid on epidural fibrosis after laminectomy: an experimental study on rats.
Article in Acta orthopaedica et traumatologica turcica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to evaluate the dose-dependent efficacy of tranexamic acid (TXA) in preventing epidural fibrosis in a rat laminectomy model and explore its potential as a therapeutic intervention for postoperative fibrosis in spinal surgery. Methods: In this experimental animal study, 32 female Wistar-Albino rats were randomized into four groups (control, 10 mg/kg TXA, 30 mg/kg TXA, and 100 mg/kg TXA; n=8 per group). Following a standardized laminectomy procedure, TXA was administered intravenously as a loading dose through the tail vein prior to surgery. The rats were sacrificed at the 4th-week post-surgery, the lumbar vertebrae were excised en bloc, and epidural fibrosis, inflammatory cell density, and fibroblast density were assessed histologically. Results: High-dose TXA (100 mg/kg) significantly reduced epidural fibrosis compared to the control (p=0.004), 10 mg/kg (p=0.002), and 30 mg/kg TXA groups (p=0.03). While the 30 mg/kg group showed lower epidural fibrosis grades compared to the control, the difference was not statistically significant. No significant differences were observed in inflammatory or fibroblast densities across groups. Conclusion: High-dose TXA (100 mg/kg) effectively reduced epidural fibrosis in a dose-dependent manner, demonstrating potential as a systemic therapeutic option to improve postoperative outcomes in spinal surgery.
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