ArticleMedicinal chemistry (Shariqah (United Arab Emirates))2026
Discovering the Cholinesterase Inhibitory Potential of Thiosemicarbazone Derivatives through
Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Synthesis of 4-Hydroxyacetophenone-Derived Bis-Schiff Bases as Potent Cholinesterase Inhibitors: In Vitro Evaluation, Molecular Docking, DFT, and ADMET Analysis.Chemistry & biodiversity · 2026Article
- Ligand and structure-based toxicological assessment of (thio)semicarbazones on cholinesterases.Journal of computer-aided molecular design · 2026Article
- Design, Synthesis, and Computational Studies of NovelACS omega · 2025Article
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10 authors.
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Abstract
backgroundThe current study explored the cholinesterase inhibitory activities of some thiosemicarbazone derivatives bearing 2,4-dichloro phenylacetic acid scaffold.
objectiveThis study aimed to screen the synthesized derivatives for their in vitro acetylcholine and butyrylcholinesterase inhibition.
methodsThese compounds were synthesized by refluxing 2,4-dichloro phenylacetic acid with sulfuric acid in ethanol to get the ester, which was further refluxed with thiosemicarbazide in ethanol to get the desired compound (2). Different benzaldehydes were treated with compound (2) in ethanol having a catalytic amount of acetic acid to get thiosemicarbazones.
resultsIn the series, seven compounds, including compounds 2c, 2a, 2b, 2d, 2g, 2e, and 2f, displayed excellent acetylcholinesterase inhibition activities in the range of IC
conclusionThese derivatives exhibited superior acetylcholinesterase and butyrylcholinesterase inhibitory activities compared to galantamine, with molecular docking and dynamic simulations confirming their strong binding affinity with the active sites of the enzymes.
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