ArticleCNS & neurological disorders drug targets2025
Unraveling the Triad: A Bioinformatics Analysis of the Interplay between Prenatal Depression, Inflammation, and the Gut Microbiota.
Article in CNS & neurological disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Protective Effects of Sodium Copper Chlorophyllin and/or Ascorbic Acid Against Barium Chloride-Induced Oxidative Stress in Mouse Brain and Liver.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrenatal depression is a prevalent mental disorder that affects women during pregnancy. Alterations in the maternal microbiota have been linked to changes in the composition of the intestinal microbiota of foetus, which can have long-term consequences for the child's health. The gut-brain axis, which involves bidirectional communication between the gut and the brain, is believed to play a role in the development of depression.
methodsThis study aimed to gather evidence for both the influence of microbiota and immunity on depression during pregnancy, using integrated bioinformatics analysis. A set of 219 differentially expressed genes (DEGs) associated with prenatal depression was established to correlate with gut inflammation. DEG data were collected from different bibliographic sources with fold change >1 and adjusted p-value <0.05. Moreover, 205 DEGs were annotated using String software.
resultsThe protein-protein interaction networks of DEGs obtained were determined by 16 main genes: DISCUSSION: The identified genes highlight key molecular interactions between the immune system, microbiota, and brain function during pregnancy. These findings support the involvement of inflammatory and microbial pathways in the development of prenatal depression.
conclusionThis study identified core genes that contribute to the understanding of the molecular mechanisms involved in the development of prenatal depression, which may serve as targets for early diagnosis, prevention, and treatment.
Indexed as
Identifiers
40357775What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.