Evidence map›Paper›PMID 40357718›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026

Epidemiology of Healthcare Facility-Associated Nontuberculous Mycobacteria From 2012 Through 2020 in a 10-Hospital Network in the United States.

Arthur W Baker, Ricardo M La Hoz, Judith A Anesi, Jennie H Kwon, Anastasia I Wasylyshyn, Emily S Ford, Susan M Harrington, Melissa B Miller, David J Weber, Emily E Sickbert-Bennett and 13 more

Abstract readMulticenter Study
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Arthur W BakerDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-0914-0291
Ricardo M La HozDivision of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-1560-3192
Judith A AnesiDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-6671-4557
Jennie H KwonDivision of Infectious Diseases, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0009-0007-9774-6835
Anastasia I WasylyshynDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0000-9939-0106
Emily S FordDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-7358-798X
Susan M HarringtonPathology and Laboratory Medicine Department, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0001-8112-0896
Melissa B MillerDepartment of Pathology & Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-0296-3535
David J WeberDivision of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Emily E Sickbert-BennettDivision of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Thomas R TalbotDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-6139-212X
M Hong NguyenDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kailey Hughes KramerDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Katelin B NickelDivision of Infectious Diseases, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-4116-512X
Matthew J ZieglerDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-5723-3927
Doramarie ArochaDepartment of Health System Infection Prevention and Control, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0009-0005-8174-7978
Charles HendersonDepartment of Health System Infection Prevention and Control, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Yuliya LokhnyginaDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
Ahmed MagedDepartment of Mechanical Engineering, Benha University, Benha, Egypt.
Salah HaridyDepartment of Mechanical Engineering, Benha University, Benha, Egypt.
Barbara D AlexanderDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.
Jason E StoutDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-6698-8176
Deverick J AndersonDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-6882-5496

Funding

Combined Use of Statistical Process Control and Whole Genome Sequencing to Detect and Investigate Nontuberculous Mycobacterial Clusters and OutbreaksK08AI163462 · NIAID · DUKE UNIVERSITY · PI BAKER, ARTHUR W · 2021 to 2025
$942k
Impact of donor bacterial infections on solid organ transplant recipient outcomesK01AI137317 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ANESI, JUDITH · 2019 to 2023
$722k
National Institute of Allergy and Infectious DiseasesNIAID NIH HHS K01 AI137317NIAID NIH HHS K08 AI163462NIH; K01-AI137317NIH; K08-AI163462NIH HHSNIH HHS K08-AI163462
6 · The paper itself

Abstract

backgroundData on the epidemiology of healthcare facility-associated (HCFA) nontuberculous mycobacteria (NTM) are sparse. We performed a multicenter longitudinal cohort study of HCFA NTM epidemiology.

methodsWe retrospectively analyzed positive cultures for NTM performed from 2012 through 2020 within a network of 10 US academic hospitals and associated clinics. A unique NTM episode was defined as a patient's first positive culture for a particular NTM species and specimen source category (pulmonary vs extrapulmonary). Episodes linked to specimens obtained on day 3 or later of hospitalization were classified as hospital-onset (HO). Seven hospitals contributed at least 12 months of data prior to January 2014. Within this closed cohort, incidence rate ratios (IRRs) and trends in incidence from 2014 through 2020 were estimated, assuming the number of episodes followed the Poisson distribution.

resultsA total of 12 855 unique NTM episodes occurred from 2012 through 2020 during 19 248 137 patient-days of surveillance. Of these episodes, 3045 (24%) were HO. HO incidence rates were highly variable among hospitals, with a median hospital rate of 1.06 episodes per 10 000 patient-days (range, 0.35-5.48). Within the 7-hospital closed cohort from 2014 through 2020, the incidence rate of HO episodes decreased from 2.29 to 1.42 episodes per 10 000 patient-days (IRR, 0.62; 95% confidence interval, .53-.73; P < .0001).

conclusionsIncidence rates of HO NTM episodes decreased from 2014 through 2020, but rates varied substantially among hospitals. These results provide comprehensive data on HO NTM isolation, including benchmark rates that can be used to improve hospital-based NTM surveillance.

Indexed as

Cross InfectionHealth FacilitiesMycobacterium Infections, NontuberculousNontuberculous MycobacteriaAdultAgedAged, 80 and overFemaleHospitalsHumansIncidenceLongitudinal StudiesMaleMiddle AgedRetrospective StudiesUnited Stateshealthcare-associated infectionshospital epidemiologyinfection preventioninfection surveillancenontuberculous mycobacteria

Identifiers

PMID40357718
PMCPMC13375574

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.