ArticleJournal of the American Heart Association2025
Impact of Statin Nonacceptance on Cardiovascular Outcomes in Patients With Diabetes.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany patients with diabetes do not accept statin therapy despite being at increased risk for cardiovascular events compared with the general population. The effects of delaying statin therapy are not well-understood.
methodsThis is a retrospective cohort study that followed adults with diabetes and no preexisting atherosclerotic cardiovascular disease at the Mass General Brigham integrated health system between 2000 and 2018. The exposure was immediate versus delayed statin acceptance by patients who were recommended statin therapy. The primary outcome was the composite incidence of myocardial infarction and ischemic stroke.
resultsAmong the 7239 study patients, the median age was 55.0 years, and 52.0% were women. Within this cohort, 1280 (17.7%) delayed statin therapy by a mean±SD of 2.7±3.1 years. Patients who delayed statin therapy had higher mean low-density lipoprotein cholesterol levels while they were not prescribed a statin (126.4 versus 99.2 mg/dL,
conclusionsAmong patients with diabetes, patients who delayed statin therapy had a significantly higher cardiovascular risk; this relationship was mediated by higher low-density lipoprotein cholesterol levels. These findings underscore the importance of timely lipid-lowering for this high-risk patient population and can help guide decision-making by patients and clinicians.
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