Evidence map›Paper›PMID 40357677›Full record

ArticleJournal of the American Heart Association2025

High-Normal Serum Potassium, Calcium, and Magnesium Levels Are Associated With Decreased Risks of Adverse Outcomes After Ischemic Stroke.

Quan Yu, Yang Liu, Xinyue Chang, Xueyu Mao, Xuechun Wu, Min Chu, Huicong Niu, Mengyao Shi, Lulu Sun, Yu He and 4 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Quan YuDepartment of Psychiatry Affiliated Guangji Hospital of Soochow University, School of Public Health, Suzhou Medical College of Soochow University Suzhou China.
Yang LiuDepartment of Neurology, Minhang Hospital Fudan University Shanghai China.ORCID 0000-0001-5939-572X
Xinyue ChangDepartment of Psychiatry Affiliated Guangji Hospital of Soochow University, School of Public Health, Suzhou Medical College of Soochow University Suzhou China.
Xueyu MaoDepartment of Neurology, Minhang Hospital Fudan University Shanghai China.ORCID 0000-0001-6143-197X
Xuechun WuDepartment of Neurology, Minhang Hospital Fudan University Shanghai China.
Min ChuDepartment of Neurology, Minhang Hospital Fudan University Shanghai China.
Huicong NiuDepartment of Neurology, Minhang Hospital Fudan University Shanghai China.ORCID 0000-0001-9112-8883
Mengyao ShiDepartment of Psychiatry Affiliated Guangji Hospital of Soochow University, School of Public Health, Suzhou Medical College of Soochow University Suzhou China.
Lulu SunDepartment of Psychiatry Affiliated Guangji Hospital of Soochow University, School of Public Health, Suzhou Medical College of Soochow University Suzhou China.
Yu HeDepartment of Psychiatry Affiliated Guangji Hospital of Soochow University, School of Public Health, Suzhou Medical College of Soochow University Suzhou China.
Yi LiuDepartment of Psychiatry Affiliated Guangji Hospital of Soochow University, School of Public Health, Suzhou Medical College of Soochow University Suzhou China.
Daoxia GuoSchool of Nursing Suzhou Medical College of Soochow University Suzhou China.
Zhengbao ZhuDepartment of Psychiatry Affiliated Guangji Hospital of Soochow University, School of Public Health, Suzhou Medical College of Soochow University Suzhou China.ORCID 0000-0001-5500-0014
Jing ZhaoDepartment of Neurology, Minhang Hospital Fudan University Shanghai China.ORCID 0000-0001-5197-9181

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh serum potassium, calcium, and magnesium levels have been reported to be associated with decreased risks of ischemic stroke, whereas their prognostic values in ischemic stroke remain unclear. We aimed to prospectively explore the associations of serum potassium, calcium, and magnesium levels with the prognosis of ischemic stroke.

methodsWe measured serum potassium, calcium, and magnesium levels at baseline among 5469 patients with ischemic stroke from the Minhang Stroke Cohort study. The primary outcome was the composite outcome of death and major disability (modified Rankin Scale score ≥3) at 3 months after ischemic stroke. Secondary outcomes included major disability, death, and the ordered 7-level categorical score of the modified Rankin Scale.

resultsDuring 3-month follow-up, 1834 patients developed the primary outcome. After multivariate adjustment, the adjusted odds ratios of primary outcome for the highest versus the lowest quartile were 0.79 (95% CI, 0.68-0.93;

conclusionsHigh-normal serum potassium, calcium, and magnesium levels were associated with decreased risks of adverse outcomes at 3 months after ischemic stroke, suggesting that serum potassium, calcium, and magnesium might be valuable prognostic biomarkers for ischemic stroke.

Indexed as

CalciumIschemic StrokeMagnesiumPotassiumAgedBiomarkersChinaFemaleHumansMaleMiddle AgedPrognosisProspective StudiesRisk AssessmentRisk FactorsTime FactorsBiomarkersCalciumMagnesiumPotassiumcalciumischemic strokemagnesiumpotassiumprognosis

Identifiers

PMID40357677
PMCPMC12184585

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.