Evidence map›Paper›PMID 40357672›Full record

ArticleJournal of the American Heart Association2025

Association of Pre-COVID Fitness With Post-COVID Fitness and Long COVID in the Cooper Center Longitudinal Cohort Study.

Matthew S Durstenfeld, David Leonard, Kelley Pettee Gabriel, Carolyn E Barlow, Kerem Shuval, Ryan Priest, Andjelka Pavlovic, Nina B Radford, Jarett D Berry, Michael J Peluso and 1 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Native T1 is independently associated with aerobic exercise capacity in long-term follow-up after mild initial COVID-19 disease (Impression COVID&Heart Study).Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matthew S DurstenfeldDivision of Cardiology Zuckerberg San Francisco General, University of California San Francisco San Francisco CA USA.ORCID 0000-0002-7612-3352
David LeonardKenneth H Cooper Institute at Texas Tech University Health Sciences Center Dallas TX USA.
Kelley Pettee GabrielDepartment of Epidemiology University of Alabama at Birmingham Birmingham AL USA.ORCID 0000-0003-4986-7927
Carolyn E BarlowKenneth H Cooper Institute at Texas Tech University Health Sciences Center Dallas TX USA.
Kerem ShuvalKenneth H Cooper Institute at Texas Tech University Health Sciences Center Dallas TX USA.
Ryan PriestKenneth H Cooper Institute at Texas Tech University Health Sciences Center Dallas TX USA.
Andjelka PavlovicKenneth H Cooper Institute at Texas Tech University Health Sciences Center Dallas TX USA.ORCID 0000-0002-4400-5466
Nina B RadfordCooper Clinic Dallas TX USA.
Jarett D BerryDepartment of Medicine UT Tyler School of Medicine Tyler TX USA.ORCID 0000-0002-5004-8155
Michael J PelusoDivision of HIV Infectious Diseases and Global Medicine at Zuckerberg San Francisco General, University of California San Francisco San Francisco CA USA.
Laura F DeFinaKenneth H Cooper Institute at Texas Tech University Health Sciences Center Dallas TX USA.ORCID 0000-0002-5753-130X

Funding

UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC)K12HL143961 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y., HUANG, LAURENCE · 2018 to 2022
$1.8M
Low Cardiorespiratory Fitness and Chronotropic Incompetence inHIV: Risk Factors, Cardiovascular Implications, and Exercise Training as TreatmentK23HL172699 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthew Durstenfeld · 2024 to 2026
$593k
NHLBI NIH HHS K12 HL143961NHLBI NIH HHS K23 HL172699
6 · The paper itself

Abstract

backgroundCross-sectional studies suggesting that SARS-CoV-2 infection and long COVID are associated with reduced cardiorespiratory fitness (CRF) lack preinfection CRF measures. The objective of this study was to determine the association of SARS-CoV-2 infection and long COVID with change in CRF.

methodsCooper Center Longitudinal Study is a cohort study based at the Cooper Clinic, a preventive medicine clinic in Dallas, Texas; we included adults ages 20 to 74 years old with CRF assessed at least twice between 2017 and 2023. COVID status was defined as "prepandemic" (2 CRF measures pre-2020), "uninfected" (no self-reported COVID), "recovered" (self-reported COVID with symptoms ≤3 months), or "long COVID" (self-reported COVID with symptoms >3 months). CRF was estimated in metabolic equivalents via a maximal modified Balke treadmill protocol.

resultsWe included 4005 participants (mean age: 51.8 years, 26.8% women), of whom, 1666 (41.6%) reported COVID and 80 (4.8% of infected) reported long COVID along with 1826 uninfected and 513 pre-pandemic controls. At baseline, those who later developed long COVID had lower CRF (10.0 metabolic equivalents, 11.1 recovered, 10.7 uninfected, 11.3 prepandemic;

conclusionsPre-COVID fitness, on average, is lower among people who developed long COVID. COVID does not greatly accelerate age-related declines in CRF, even among some with long COVID, although few included participants had severely disabling long COVID. Future longitudinal research will clarify if differences in CRF by infection status emerge over longer follow-up.

Indexed as

Cardiorespiratory FitnessCOVID-19AdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedPost-Acute COVID-19 SyndromeSARS-CoV-2TexasYoung Adultcardiorespiratory fitnessCOVID‐19SARS‐CoV‐2

Identifiers

PMID40357672
PMCPMC12184544

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.