Retrograde inferior vena cava perfusion reduces the risk of acute kidney injury depending on the oxygen extraction ratio. A retrospective cohort study.

Xinyi Liao, Dan Luo, Jing Lin, Zhaoxia Tan, Jiyue Xiong, Lei Du

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Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Xinyi Liao *Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Dan Luo *Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Jing LinDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Zhaoxia TanDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Jiyue XiongDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Lei DuDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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6 · The paper itself

Abstract

Background: Total aortic arch replacement surgery (TARS) for Acute type A aortic dissection is associated with high incidence of postoperative acute kidney injury (AKI), at least partly due to the lower body ischemia during circulatory arrest. This study aimed to evaluate whether retrograde inferior vena cava perfusion (RIVP) reduces the risk of AKI by providing oxygenated blood to the lower body. Methods: This retrospective study utilized a medical recording system to screen patients who underwent TARS from January 1 to December 31, 2019. Patients were assigned to receive antegrade cerebral perfusion (ACP) only or ACP + RIVP during circulatory arrest. The primary outcome was postoperative AKI. Oxygen delivery, consumption, and extraction ratio during RIVP were also determined. Results: Of all included 87 patients, postoperative AKI occurred in 35 (40%), of whom 23 (53.5%) were in the ACP, and 12 (27.3%) were in the ACP + RIVP ( Conclusion: RIVP may reduce the risk of postoperative AKI in a manner that depends on the tissue oxygen extraction ratio.

Indexed as

acute kidney injuryacute type A aortic dissectionantegrade cerebral perfusionERO2retrograde inferior vena cava perfusion

Identifiers

PMID40357441

DOI10.3389/fcvm.2025.1514247

PMCPMC12066508

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