Evidence map›Paper›PMID 40357395›Full record

ReviewFrontiers in cellular and infection microbiology2025

Wound repair and immune function in the

Emma Lea Matthews, Meghan June Hirsch, Federico Prokopczuk, Luke I Jones, Eriel Martínez, Jarrod W Barnes, Stefanie Krick

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emma Lea Matthews *Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Meghan June Hirsch *Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Federico ProkopczukDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, AL, United States.
Luke I JonesDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Eriel MartínezDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, AL, United States.
Jarrod W BarnesDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Stefanie KrickDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.

Funding

Targeting fibroblast growth factor receptors in cystic fibrosis-associated airway inflammation and mucociliary dysfunctionR01HL160911 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stefanie Krick · 2022 to 2026
$2.1M
Epigenetic Modulation of Cellular Senescence in the Cystic Fibrosis LungR01HL169253 · NHLBI · OLD DOMINION UNIVERSITY · PI Stefanie Krick, Yan Sanders · 2024 to 2026
$1.9M
The essentiality of serine and glycine for skeletal muscle regeneration in agingR01AG075059 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THALACKER-MERCER, ANNA E. · 2022 to 2025
$1.5M
Training Program in Cell, Molecular, and Developmental BiologyT32GM146611 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Susan L Bellis · 2024 to 2026
$1.4M
NHLBI NIH HHS R01 HL160911NHLBI NIH HHS R01 HL169253NIA NIH HHS R01 AG075059NIGMS NIH HHS T32 GM146611
6 · The paper itself

Abstract

The leading cause of death for people with cystic fibrosis (pwCF) continues to be due to respiratory-related illnesses. Both wound repair and immune cell responses are dysregulated in the CF airways, creating a cycle of unresolved injury and perpetuating inflammation. PwCF are predisposed to colonization and infections with opportunistic bacteria like

Indexed as

Cystic FibrosisLungPseudomonas InfectionsWound HealingAminophenolsBenzodioxolesHumansPseudomonas aeruginosaQuinolonesAminophenolsBenzodioxolesivacaftorQuinolonesbronchial epitheliumcystic fibrosiselexacaftor/tezacaftor/ivacaftor(ETI)immune systemmodulator therapyPseudomonas aeruginosawound repair

Identifiers

PMID40357395
PMCPMC12066499

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.