Evidence map›Paper›PMID 40357335›Full record

ArticleNature machine intelligence2024

Data-Driven Discovery of Movement-Linked Heterogeneity in Neurodegenerative Diseases.

Mark Endo, Favour Nerrise, Qingyu Zhao, Edith V Sullivan, Li Fei-Fei, Victor W Henderson, Kilian M Pohl, Kathleen L Poston, Ehsan Adeli

Abstract read
In one paragraph

Article in Nature machine intelligence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. [Research progress in motor assessment of neurodegenerative diseases driven by motion capture data].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mark EndoDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Favour NerriseDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Qingyu ZhaoDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Edith V SullivanDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Li Fei-FeiDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Victor W HendersonDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Kilian M PohlDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Kathleen L PostonDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Ehsan AdeliDepartment of Computer Science, Stanford University, Stanford, CA, USA.

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Lisa Goldman Rosas · 2020 to 2026
$29.0M
TRACKING HIV INFECTION AND ALCOHOL ABUSE CNS COMORBIDITY WITH NEUROIMAGINGU01AA017347 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, SULLIVAN, EDITH VIONI · 2007 to 2021
$16.0M
NCANDA: Data Analysis Resource - Uploading Legacy Data to NDAU24AA021697 · NIAAA · STANFORD UNIVERSITY · PI Adolf Pfefferbaum, Kilian Maria Pohl · 2016 to 2026
$12.2M
CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISMR01AA010723 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI, ZAHR, NATALIE M · 1996 to 2025
$8.3M
Working Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI HENDERSON, VICTOR · 2015 to 2019
$7.9M
Machine learning to distinguish HAND from Alzheimer's disease in HIV over age 60R01MH113406 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POHL, KILIAN MARIA, VALCOUR, VICTOR · 2017 to 2021
$5.5M
Cerebellar Structure and Function in AlcoholismR37AA010723 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2010 to 2019
$5.4M
Tracking HIV Infection & Alcohol Abuse CNS Comorbidity with NeuroimagingR01AA017347 · NIAAA · SRI INTERNATIONAL · PI Adolf Pfefferbaum · 2022 to 2026
$5.2M
Neural mechanisms of gait disturbances as individualized digital biomarker trajectories in preclinical dementiaR01AG089169 · NIA · STANFORD UNIVERSITY · PI Ehsan Adeli · 2024 to 2026
$4.5M
NIAAA NIH HHS R01 AA010723NIAAA NIH HHS R01 AA017347NIAAA NIH HHS R37 AA010723NIAAA NIH HHS U01 AA017347NIAAA NIH HHS U24 AA021697NIA NIH HHS P30 AG066515NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG089169NIMH NIH HHS R01 MH113406
6 · The paper itself

Abstract

Neurodegenerative diseases manifest different motor and cognitive signs and symptoms that are highly heterogeneous. Parsing these heterogeneities may lead to an improved understanding of underlying disease mechanisms; however current methods are dependent on clinical assessments and somewhat arbitrary choice of behavioral tests. Herein, we present a data-driven subtyping approach using video-captured human

Indexed as

canonical correlation analysisdigital biomarkersfunctional connectivityhuman motion analysisParkinson’s diseasesubtyping

Identifiers

PMID40357335
PMCPMC12068835

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.