Evidence map›Paper›PMID 40357329›Full record

ReviewFrontiers in bioengineering and biotechnology2025

Urine-derived stem cells: a sustainable resource for advancing personalized medicine and dental regeneration.

Gamal A Atia, Ahmed Abdal Dayem, Ehab S Taher, Wafaa Y Alghonemy, Ssang-Goo Cho, Ahmed A Aldarmahi, Md Azizul Haque, Abeer Alshambky, Noha Taymour, Ateya M Ibrahim and 7 more

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gamal A Atia *Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.
Ahmed Abdal Dayem *Department of Stem Cell and Regenerative Biotechnology, School of Advanced Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, and Institute of Health, Aging & Society, Konkuk University, Seoul, Republic of Korea.
Ehab S TaherDepartment of Basic and Clinical Medical Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan.
Wafaa Y AlghonemyDepartment of Basic and Clinical Medical Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan.
Ssang-Goo ChoDepartment of Stem Cell and Regenerative Biotechnology, School of Advanced Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, and Institute of Health, Aging & Society, Konkuk University, Seoul, Republic of Korea.
Ahmed A AldarmahiDepartment of Basic Science, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Md Azizul HaqueDepartment of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea.
Abeer AlshambkyMolecular Therapeutics Program, Fox Chase Cancer Center, Temple University, Philadelphia, PA, United States.
Noha TaymourDepartment of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Ateya M IbrahimCollege of Nursing, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Donia E ZaghamirCollege of Nursing, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Ekramy M ElmorsyCenter for Health Research, Northern Border University, Arar, Saudi Arabia.
Helal F HettaDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
Mohamed E MohamedDepartment of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia.
Kasim S AbassDepartment of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Kirkuk, Kirkuk, Iraq.
Shifan KhandayDepartment of Biomedical Sciences, Dubai Medical College for Girls, Dubai Medical University, Dubai, United Arab Emirates.
Ahmed AbdeenDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urine-based therapy, an ancient practice, has been utilized across numerous civilizations to address a wide range of ailments. Urine was considered a priceless resource in numerous traditional therapeutic applications due to its reported medicinal capabilities. While the utilization of urine treatment is contentious and lacks significant support from modern healthcare, the discovery of urine-derived stem cells (UDSCs) has introduced a promising avenue for cell-based therapy. UDSCs offer a noninvasive and easily repeatable collection method, making them a practical and viable option for therapeutic applications. Research has shown that UDSCs contribute to organ preservation by promoting revascularization and decreasing inflammatory reactions in many diseases and conditions. This review will outline the contemporary status of UDSCs research and explore their potential applications in both fundamental science and medical practice.

Indexed as

biomaterialscartilage repairdisease modelingexosomesnon‐invasive cell therapyregenerative medicinetissue engineering

Identifiers

PMID40357329
PMCPMC12066649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.