ArticleFrontiers in medicine2025
Fatigue and associated factors in men with rheumatoid arthritis: a case-control study using the FACIT-F scale.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Beyond Disease Activity: Fatigue and Health-Related Quality of Life in Rheumatoid Arthritis Remission and Low Disease Activity.Journal of clinical medicine · 2026Article
- Geroscience insights into difficult-to-treat rheumatoid arthritis: the role of unhealthy aging, comorbidity, and therapeutic complexity.GeroScience · 2026Review
- Evaluating usability, adherence and clinical benefit of a new digital heath application in rheumatoid arthritis: a pilot feasibility study.Rheumatology international · 2026Article
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Authors and funding
9 authors.
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Abstract
Introduction: Fatigue is a debilitating condition commonly reported in rheumatoid arthritis (RA), yet its prevalence and associated factors in men remain underexplored. This study investigates the prevalence and severity of fatigue in Spanish men over 50 years with RA. Methods: A case-control study was conducted at a university hospital, comprising 84 RA patients (mean age: 71.9 ± 8.5 years) and 102 age-matched controls. Fatigue was assessed using the FACIT-F scale, together with evaluations of inflammatory markers (CRP, ESR), disease activity (DAS28, RAPID3), disability (HAQ), and health-related quality of life (SF-12). Group differences were examined, and correlations were analyzed to investigate associations between fatigue and RA-related parameters. Stepwise regression analysis was performed to identify independent predictors of fatigue. Results: Rheumatoid arthritis patients exhibited greater fatigue compared to controls, with a median FACIT-F score of 41.5 (38; 46.8) versus 46.25 (38; 49) ( Conclusion: Fatigue is a significant comorbidity in men with RA, closely linked to inflammation, disease activity and reduced quality of life.
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