ArticleFrontiers in medicine2025
Immunocytochemical examination of Akt, mTOR, and Pax-2 for endometrial carcinoma through thin-layer endometrial cytology.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- AI-driven radiogenomics in gynecologic oncology: from radiological digital biopsy to a new paradigm in precision therapy.Frontiers in oncology · 2026Review
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Authors and funding
8 authors.
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Abstract
Objective: This study aimed to detect the expression of Akt, mTOR, and Pax-2 in differing endometrial tissue/cells, together with assessment of such molecular markers for improving accuracy within endometrial cytology screening for endometrial cancer (EC). Methods: Overall, 92 hysteroscopy cases were included. This cohort comprised 32 endometrial carcinoma patients, 30 benign lesion patients, and 30 cases with normal endometrium. Endometrial cells were collected before hysteroscopy, for immunohistochemical (IHC) and immunocytochemical (ICC) detection of Akt, mTOR, and Pax-2. Expression levels were evaluated by semi-quantitative method, and ROC curves (Receiver Operating Characteristic Curve) were drawn to evaluate the application importance for all three biomarkers for EC diagnostics. Results: IHC expression of Akt, mTOR, and Pax-2 was positively correlated with ICC expression within the endometrial carcinoma cohort, benign lesion cohort, and normal cohort. Using IHC and ICC, Akt/mTOR-marked upregulation was observed within the EC cohort, compared to all other cohorts. Pax-2 was also markedly upregulated within normal/benign lesion cohorts in comparison to the EC cohort ( Conclusion: This investigation probed varying threshold levels pertaining to Akt, mTOR, and Pax-2, consequently assisting in endometrial lesion-type identification. IHC within ECT (endometrial cytology test) analyses for Akt, mTOR, and Pax-2 could enhance the capacity for diagnosing EC/pre-malignant lesions.
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