ArticleFrontiers in medicine2025
Comparison of progesterone-modified natural cycle and hormone replacement therapy cycle for endometrial preparation in single frozen blastocyst transfer (COMPROSET): protocol for an open-label randomized controlled trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06644794 (Comparison of Progesterone-modified Natural Cycle and Hormone Replacement Therapy Cycle for Endometrial Preparation in Single Frozen Blastocyst Transfer), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Progesterone-modified Natural Cycle and Hormone Replacement Therapy Cycle for Endometrial Preparation in Single Frozen Blastocyst Transfer
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: As infertility incidence increases gradually, frozen-thawed embryo transfer (FET) techniques are continuously being developed and enhanced. Although endometrial preparation regimens are strongly linked to live birth rates (LBR), there has been controversy over the ideal regimen. Hormone replacement therapy (HRT) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (NC). By ensuring the presence of the corpus luteum while reducing the number of monitoring sessions, the progesterone modified natural cycle (P Methods and analysis: This study is a single-center, open-label, randomized controlled trial (RCT) targeting to recruit a total of 672 women, with 336 individuals each in two arms (1:1 treatment ratio). Women undergoing in vitro fertilization (IVF) scheduled for a single frozen-thawed blastocyst transfer (FBT) and who have regular menstrual cycles are eligible. After signing an informed consent form, patients will be randomized into two groups: the P4mNC group and the HRT group. The primary objective is to determine whether P Ethics and dissemination: This study is approved by the Institutional Review Board of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Reference No. 2024-144-KY). The results of our study will be submitted to reproductive medicine conferences and journals. Clinical trial registration: ClinicalTrials.gov, identifier NCT06644794.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.