Evidence map›Paper›PMID 40357256›Full record

ArticleJournal of multidisciplinary healthcare2025

Neonatal Hearing Loss Risk Factors and miRNA Biomarkers Identified Through AABR Screening.

Min Huang, Yunlong Jing, Xiangyue Peng, Jiang Xie, Qin Zhao, Jiang-Long Yin, Wen-Du Xiao, Si-Jun Zhao, Hong-Ju Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Min Huang *Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children's Hospital, Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, 410007, People's Republic of China.
Yunlong Jing *Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children's Hospital, Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, 410007, People's Republic of China.
Xiangyue PengDepartment of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children's Hospital, Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, 410007, People's Republic of China.
Jiang XieDepartment of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children's Hospital, Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, 410007, People's Republic of China.
Qin ZhaoDepartment of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children's Hospital, Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, 410007, People's Republic of China.
Jiang-Long YinDepartment of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children's Hospital, Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, 410007, People's Republic of China.
Wen-Du XiaoDepartment of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children's Hospital, Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, 410007, People's Republic of China.
Si-Jun ZhaoDepartment of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Children's Hospital, Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, Hunan, 410007, People's Republic of China.
Hong-Ju TianObstetrics and Gynecology Center of Hunan Occupational Disease Prevention and Control Institute, Changsha, 410007, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To determine the prevalence of hearing impairment in neonates and identify associated risk factors through auditory brainstem response (ABR) screening. Study Design: A prospective observational longitudinal study was conducted involving 158 infants, with Automated Auditory Brainstem Response (AABR) evaluations performed by 6 months of age. Setting: The study was undertaken in a hospital-based neonatal care unit. Methods: Infants with significant hearing loss in one or both ears were referred for further assessment and rehabilitation. The relationship between microRNAs (MiRNAs) and congenital hearing loss was confirmed through differential expression levels in newborns. Results: Of the 158 infants, 8 showed abnormal AABR results. Univariable analysis identified 5 potential risk factors associated with hearing deterioration, with multivariable analysis pinpointing the number of maternal embryos, cytomegalovirus, and miR-431 as independently associated with hearing loss at 6 months ( Conclusion: Early detection of hearing loss is vital for child development. Given the high incidence of hearing impairment in the study population, universal newborn hearing screening is essential. Assessment of miRNAs expression levels, maternal embryo count, and prenatal infections should be integrated into screening protocols for infants admitted for over 24 hours to prevent oversight of neural hearing loss cases.

Indexed as

automated auditory brainstem responsefactors affecting hearing disordersneonatal screening

Identifiers

PMID40357256
PMCPMC12068383

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.