ArticleFrontiers in aging neuroscience2025
Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Actigraphy is widely used to detect a decline in physical activity in aged individuals with cerebral small vessel disease (cSVD). Disturbed fractal physical activity has been reported in aged adults with Alzheimer's disease (AD), mild cognitive impairment (MCI), and other neuropsychiatric disorders. Objectives: To analyze the fractal physical activity pattern in elderly patients with cSVD. Methods: From May 2021 to August 2023, 55 patients with cSVD aged 60-80 years admitted to the seventh medical center of PLA General Hospital were included. The presence of lacunes, white matter hyperintensities, cerebral microbleeds, and perivascular spaces on magnetic resonance images (MRI) were rated independently. Furthermore, these MRI markers were summed in a score of 0-4, representing all cSVD features combined. Detrended fluctuation analysis (DFA) was used to evaluate the fractal physical activity fluctuations at multiple time scales. The relationship between the fractal physical activity pattern and physical activity and sleep quality was analyzed with partial Pearson correlation analysis. Results: Individuals with a low severity cSVD burden showed a significant tendency toward a random fractal pattern relative to those with a higher severity cSVD burden. Similar results were obtained when comparing the lacune positive and negative groups. In aged adults with cSVD, fractal disturbance was associated with an average level of physical activity and not sleep quality. Conclusion: These findings demonstrate the presence of obvious fractal physical activity complexity in aged adults with cSVD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.