ArticleFrontiers in endocrinology2025
Causal relationship between plasma lipidome and rosacea: a Mendelian randomization analysis.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The lipid-inflammation axis in rosacea: mechanistic insights and therapeutic implications.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Rosacea is a common chronic inflammatory skin disease. Limited studies reported the association between plasma lipidome and rosacea. Methods: We employed a two-sample Mendelian randomization (MR) study to assess the causality between plasma lipidome and rosacea. Plasma lipidome association genome-wide association study (GWAS) data were collected. The inverse variance weighted (IVW) method was utilized as the principal method in our Mendelian randomization (MR) study; we also used the MR-Egger, weighted median, simple mode, and weighted mode methods. The MR-Egger intercept test, Cochran's Q test, MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and leave-one-out analysis were conducted to identify heterogeneity and pleiotropy. Results: A total of 179 lipid species were analyzed; among them, five lipid species were closely related to rosacea. Two species of sterol ester [sterol ester (27:1/22:6) and sterol ester (27:1/15:0)], two species of phosphatidylethanolamine [phosphatidylethanolamine (O-18:2_20:4) and phosphatidylethanolamine (18:0_20:4)], and one species of sphingomyelin [sphingomyelin (d34:0)] were causally associated with rosacea ( Conclusion: This study provided new evidence of the relationship between plasma lipidome and rosacea. Our MR suggested that five lipid species play protective roles in rosacea progression. These could be novel and effective ways to treat rosacea.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.