Evidence map›Paper›PMID 40357016›Full record

ArticleBrain communications2025

Leveraging interictal multimodal features and graph neural networks for automated planning of epilepsy surgery.

Petr Nejedly, Valentina Hrtonova, Martin Pail, Jan Cimbalnik, Pavel Daniel, Vojtech Travnicek, Irena Dolezalova, Filip Mivalt, Vaclav Kremen, Pavel Jurak and 4 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Petr NejedlyBrno Epilepsy Center, Department of Neurology, Member of ERN-EpiCARE, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Valentina HrtonovaBrno Epilepsy Center, Department of Neurology, Member of ERN-EpiCARE, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Martin PailBrno Epilepsy Center, Department of Neurology, Member of ERN-EpiCARE, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Jan CimbalnikInternational Clinical Research Center, St. Anne's University Hospital, Brno 602 00, Czech Republic.
Pavel DanielBrno Epilepsy Center, Department of Neurology, Member of ERN-EpiCARE, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Vojtech TravnicekBrno Epilepsy Center, Department of Neurology, Member of ERN-EpiCARE, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Irena DolezalovaBrno Epilepsy Center, Department of Neurology, Member of ERN-EpiCARE, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Filip MivaltDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-0693-9495
Vaclav KremenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0001-9844-7617
Pavel JurakInstitute of Scientific Instruments, The Czech Academy of Sciences, Brno 612 00, Czech Republic.
Gregory A WorrellDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Birgit FrauscherDepartment of Neurology, Duke University Medical Center, Durham, NC 27705, USA.
Petr KlimesBrno Epilepsy Center, Department of Neurology, Member of ERN-EpiCARE, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.
Milan BrazdilBrno Epilepsy Center, Department of Neurology, Member of ERN-EpiCARE, St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise localization of the epileptogenic zone is pivotal for planning minimally invasive surgeries in drug-resistant epilepsy. Here, we present a graph neural network (GNN) framework that integrates interictal intracranial EEG features, electrode topology, and MRI features to automate epilepsy surgery planning. We retrospectively evaluated the model using leave-one-patient-out cross-validation on a dataset of 80 drug-resistant epilepsy patients treated at St. Anne's University Hospital (Brno, Czech Republic), comprising 31 patients with good postsurgical outcomes (Engel I) and 49 with poor outcomes (Engel II-IV). The GNN predictions demonstrated a significantly better (

Indexed as

epilepsygraph neural networksiEEGMRIsurgery

Identifiers

PMID40357016
PMCPMC12066826

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.