Evidence map›Paper›PMID 40356957›Full record

ArticleFrontiers in pharmacology2025

Charting the COVID-19 vaccination journey in Saudi Arabia: Insights into post-vaccination adverse effects and immunization dynamics.

Gehad M Subaiea, Nawaf Alkhateeb, Faisal Sahman, Abdulrahman Alsudayri, Abdulkarim M Almudayni, Hamoud Alrashidi, Abdulrahman M Alshammari, Abdulwahab Alamri, Sultan Almuntashiri, Arshad Hussain and 2 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gehad M SubaieaDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Nawaf AlkhateebCollege of Pharmacy, University of Hail, Hail, Saudi Arabia.
Faisal SahmanCollege of Pharmacy, University of Hail, Hail, Saudi Arabia.
Abdulrahman AlsudayriCollege of Pharmacy, University of Hail, Hail, Saudi Arabia.
Abdulkarim M AlmudayniCollege of Pharmacy, University of Hail, Hail, Saudi Arabia.
Hamoud AlrashidiCollege of Pharmacy, University of Hail, Hail, Saudi Arabia.
Abdulrahman M AlshammariCollege of Pharmacy, University of Hail, Hail, Saudi Arabia.
Abdulwahab AlamriDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Sultan AlmuntashiriDepartment of Clinical Pharmacy, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Arshad HussainDepartment of Clinical Pharmacy, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Heba Ali KhloofiDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail, Saudi Arabia.
Sirajudheen AnwarDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The current study evaluated the effects of different COVID-19 vaccines on Saudi Arabian residents, focusing on their safety, acceptance, and effectiveness. Gaining a better knowledge of these vaccination results will help develop more successful public health initiatives and increase confidence in vaccination campaigns throughout the Kingdom. Methods: A cross-sectional study was conducted with 401 participants from diverse backgrounds, covering different ages, genders, nationalities, weights, and education levels. The survey gathered information about participants' health conditions, their vaccines, side effects, and infection rates before and after vaccination. The data were analyzed to compare vaccine preferences, side effects, and infection trends overtime. Results: Sociodemographic-wise, most participants were men (62.84%) and Saudi nationals (96.01%), showing significant differences by gender and nationality (P < 0.001). The largest age group was 21-30 years (45.89%, P < 0.001), with 66.58% being university graduates (P < 0.001). Pfizer/BioNTech was the top choice across all doses, with 83.46% receiving it for the first dose, 78.1% for the second, and 39.28% for the third, reflecting a clear preference over other vaccines (P < 0.001). Pfizer/BioNTech recipients reported side effects after the first dose in 36.53% of cases, but only 1.86% needed medical help. Vaccination significantly reduced infection rates: Pfizer/BioNTech dropped infection rates from 43.18% to 8.33% after the third dose (P < 0.001), while Oxford/AstraZeneca saw rates fall from 12.88% to 0.76% after the third dose, but did not reach significance (P = 0.34). Overall, vaccinated individuals had much lower infection rates (28.17%) than among unvaccinated ones (100%), with a P-value of 0.020. Conclusion: Our results concluded that Saudi Arabia's vaccination campaign has proven effective, especially after the second and third doses. Pfizer/BioNTech was the most preferred vaccine, demonstrating strong efficacy and safety, which helped build public confidence. Ongoing monitoring is crucial to maintaining pandemic control, post-marketing and public health strategies.

Indexed as

adverse effectscross-sectional studyformatted: numbering: continuous COVID-19 vaccinationinfection ratesSaudi Arabiasocio demographic characteristicsvaccine administration

Identifiers

PMID40356957
PMCPMC12066665

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.