Evidence map›Paper›PMID 40356952›Full record

ReviewFrontiers in pharmacology2025

Exosomes as natural vectors for therapeutic delivery of bioactive compounds in skin diseases.

Somayeh Keshtkar, Zahra Asvar, Haniyeh Najafi, Mozhdeh Heidari, Maryam Kaviani, Fatemeh Sabet Sarvestani, Ali Mohammad Tamaddon, Maryam Sadat Sadati, Nasrin Hamidizadeh, Negar Azarpira

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Somayeh KeshtkarMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra AsvarNanotechnology School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Haniyeh NajafiDepartment of Pharmaceutical Nanotechnology, Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.
Mozhdeh HeidariTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam KavianiTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Fatemeh Sabet SarvestaniTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ali Mohammad TamaddonDepartment of Pharmaceutical Nanotechnology, Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam Sadat SadatiMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Nasrin HamidizadehMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Negar AzarpiraTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin diseases are a broad category of diseases and each has complex conditions, which makes it challenging for dermatologists to provide targeted treatment. Exosomes are natural vesicles secreted by cells and play a key role in cell communication. Due to their unique characteristics, including inherent stability, minimal immunogenicity, high biocompatibility, and exceptional ability to penetrate cells, exosomes are being explored as potential delivery vehicles for therapeutics across various diseases including skin problems. Utilizing exosomes for drug delivery in skin diseases can improve treatment outcomes and reduce the side effects of traditional drug delivery methods. Indeed, exosomes can be engineered or utilized as an innovative approach to deliver therapeutic agents such as small molecule drugs, genes, or proteins specifically to affected skin cells. In addition to targeting specific skin cells or tissues, these engineered exosome-based nanocarriers can reduce off-target effects and improve drug efficacy. Hence, this article highlights the transformative potential of this technology in revolutionizing drug delivery in dermatology and improving patient outcomes.

Indexed as

deliverydrugexosomesgenetic agentproteinskin diseases

Identifiers

PMID40356952
PMCPMC12066514

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.