ArticleFrontiers in public health2025
Global shifts in osteoarthritis subtype trends among older adults due to elevated BMI: an age-period-cohort analysis based on the global burden of disease database.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Global prevalence, incidence, and years lived with disability (YLDs) of osteoarthritis: trends from 1990 to 2021 and projections to 2050.Journal of orthopaedic translation · 2026Article
- Molecular mediators of motion: RNA-RBP networks in exercise-induced osteoarthritis protection.Frontiers in genetics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: It remains unclear whether elevated Body Mass Index(BMI)has a similar impact on the disease burden of osteoarthritis subtypes in older adults. This study aims to compare the long-term trends of osteoarthritis subtypes caused by high BMI across different gender groups globally from 1990 to 2021. Methods: We obtained cross-sectional data from the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2021 (https://vizhub.healthdata.org/gbd-results/). The disease burden of osteoarthritis subtypes in older adults attributable to high BMI was quantified using Years Lived with Disability (YLDs). Linear regression and the Age-Period-Cohort (APC) method were employed to calculate the trends in Age-standardized Years lived with disability rate (ASYR), adjusting for age, period, and cohort effects. Results: The ASYR of osteoarthritis attributable to high BMI in older adults globally has shown a continuous upward trend over the past 32 years, with an Estimated Average Percentage Change (EAPC) of 0.96 (95% CI: 0.94 to 0.99). Specifically, the EAPC for hip osteoarthritis was 0.73 (95% CI: 0.70 to 0.76), while for knee osteoarthritis, it was 0.99 (95% CI: 0.96 to 1.02). China recorded the highest number of osteoarthritis YLDs globally, reaching 0.59 million (95% UI: -0.05 to 1.71). The United States had one of the highest ASYR rates for osteoarthritis at 410.85 per 100,000 (95% UI: -44.47 to 1,083.52), while India exhibited the highest EAPC for osteoarthritis worldwide at 2.74 (95% CI: 2.70 to 2.79), with hip osteoarthritis at 3.36 (95% CI: 3.25 to 3.48) and knee osteoarthritis at 2.70 (95% CI: 2.65 to 2.75). The local drift curves indicated a slow upward trend in the annual percentage change of YLDs for both hip and knee osteoarthritis attributable to high BMI across all age groups. In terms of gender, males exhibited a higher rate and risk of YLDs associated with high BMI. Conclusion: Our findings provide strong evidence that the ASYR associated with high BMI globally have continuously increased over the past 32 years, with consistent patterns of change observed across different osteoarthritis subtypes. This highlights the critical role of BMI control in effectively alleviating the burden of osteoarthritis in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.