SynthesisFrontiers in public health2025
Chloroform exposure and risk of leukemia: systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Association of fermented dairy consumption with asthma and wheeze risk in children: a systematic review and meta-analysis of observational studies.Frontiers in nutrition · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The aim of this systematic review and meta-analysis was to evaluate the association between chloroform exposure and the risk of leukemia, quantify the overall risk, and identify potential sources of heterogeneity among different leukemia subtypes. Methods: A comprehensive literature search was conducted across PubMed, Web of Science, and Scopus to identify relevant epidemiological studies published up to December 2023. Inclusion criteria focused on human studies that assessed chloroform exposure and reported leukemia incidence or mortality. Data were extracted and analyzed using random-effects models to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs). Heterogeneity was assessed using I Results: Four case-control studies were included, spanning publication years from 2001 to 2023, with sample sizes ranging from 67 to 31,292 participants. The overall pooled OR for the association between chloroform exposure and leukemia was 0.75 (95% CI: 0.25-2.27), indicating no statistically significant association. However, substantial heterogeneity was observed (I Conclusion: This systematic review and meta-analysis did not find a significant overall association between chloroform exposure and leukemia risk. The significant association observed for AML suggests that chloroform exposure might increase the risk of this specific subtype, while the reduced risk for CLL warrants further investigation. The high heterogeneity underscores the need for standardized methodologies and further research to clarify these associations, particularly focusing on different leukemia subtypes, exposure levels, and population characteristics. These findings can inform public health policies and targeted prevention strategies to mitigate potential risks associated with chloroform exposure. Clinical trial registration/systematic review registration: https://www.waocp.com/journal/index.php/apjec/article/view/1283.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.