ArticleFrontiers in public health2025
Association between cognitive function and Cre/BW in middle-aged and older Chinese adults: evidence from the CHARLS.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cre/BW has been widely validated as a reliable biomarker for assessing muscle mass in clinical and epidemiological studies. Accumulating evidence from longitudinal cohort studies has demonstrated a significant association between sarcopenia and progressive cognitive decline in aging populations. To further elucidate this relationship, we conducted a comprehensive analysis using data from a nationally representative survey. Methods: This study utilized longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS), with baseline measurements collected in 2012 and follow-up assessments conducted in 2018. To comprehensively evaluate the association between Cre/BW and cognitive function, we employed a dual analytical approach. Cross-sectional analyses were performed using multivariable-adjusted linear regression models for continuous cognitive scores and logistic regression models for dichotomous cognitive outcomes. For longitudinal assessment, we implemented time-to-event analyses using Cox proportional hazards models, with rigorous adjustment for potential confounders including demographic characteristics, lifestyle factors, and comorbidities. Results: Initial unadjusted linear regression analysis revealed a significant inverse association between Cre/BW ratio and total cognitive function score ( Conclusion: Our findings demonstrate a significant inverse association between Cre/BW and cognitive function in the general Chinese adult population. Longitudinal analysis revealed that elevated Cre/BW ratio serves as an independent risk factor for cognitive impairment, with this association persisting after extended follow-up and comprehensive adjustment for potential confounding factors.
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