Evidence map›Paper›PMID 40356788›Full record

ArticleJCEM case reports2025

Co-Occurrence of Hypophysitis and Thyroiditis Induced by PD-L1 Inhibitor Avelumab: Clinical Insights.

Zhanna Zavgorodneva, Muzammil Khan, Helena Guber

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhanna ZavgorodnevaDivision of Endocrinology, Diabetes & Metabolism, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY 11209, USA.ORCID https://orcid.org/0009-0009-9021-8604
Muzammil KhanDivision of Endocrinology, Diabetes & Metabolism, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY 11209, USA.
Helena GuberDivision of Endocrinology, Diabetes & Metabolism, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY 11209, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various endocrinopathies have been described in patients with malignancies who are receiving treatment with immune checkpoint inhibitors (ICIs). We present the case of a patient who was hospitalized with an acute alteration in mental status and was referred to the endocrinology service for evaluation of abnormal thyroid function tests. Subsequent investigation revealed the presence of acute adrenal insufficiency, which was successfully managed with steroid replacement therapy. This case highlights a unique simultaneous presentation of thyrotoxicosis due to thyroiditis and adrenal insufficiency due to hypophysitis in a patient treated with ICI avelumab for 5 months.

Indexed as

endocrinopathyhypophysitisimmune checkpoint inhibitorsthyroiditis

Identifiers

PMID40356788
PMCPMC12066409

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.